Markers of neural degeneration and regeneration in Down syndrome patients
Joint Authors
Abd al-Majid, Iman Ihsan
Abd al-Salam, Ikram
Abd al-Latif, Duaa M.
Kurraa, Suhayr
Ismail, Amal
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 14, Issue 1 (31 Jan. 2013), pp.49-53, 5 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2013-01-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
On the trisomy Down syndrome Critical Region (DSCR1) is located the APP gene, which accelerates amyloid peptide protein (APP) expression leading to cerebral accumulation of APP-derived amyloid-beta peptides (Ab) and age-dependent cognitive sequelae.
Also DSCR1 attenuates endothelial cell proliferation and angiogenesis required for tissue repair.
The aim of the present work is to determine markers of neural degeneration and regeneration in the blood of young and adolescent Down syndrome (DS) patients as well as controls.
Markers of regeneration were measured in terms of circulating mononuclear cells expressing Nestin and CD34, while markers of degeneration were measured in terms of plasma Ab42 and advanced glycation end products receptors (RAGES).
Results showed a significant increase in plasma Ab42 (20 ± 5.1 vs.
11.9 ± 3.4) and RAGES leucocytes mRNA relative expression (1.9 ± 0.2 vs.
1.1 ± 0.6) in adolescent DS patients compared to young DS.
Both parameters were also significantly increased in DS compared to controls : Ab42 (15.4 ± 5.9 vs.
12.
3 ± 4.5) ; RAGES (1.4 ± 0.5 vs.
0.7 ± 0.2).
Nestin (5.2 ± 1.4 vs.
6.3 ± 0.6) and CD34 (52 ± 2.5 vs.
53 ± 4.7) were non-significantly lower in adolescent DS patients compared to young DS, but significantly lower in DS patients compared to controls : Nestin (6.3 ± 1.5 vs.
9 ± 4.4) ; CD34 (54 ± 3.4 vs.
60 ± 4.8).
The significant decrease in the number of mononuclear cells bearing Nestin and CD34 markers accompanied by a significant increase in Ab42 and RAGES indicate that degeneration in DS is an ongoing process, which is not counterbalanced by the regenerative mechanism.
American Psychological Association (APA)
Abd al-Majid, Iman Ihsan& Abd al-Salam, Ikram& Abd al-Latif, Duaa M.& Kurraa, Suhayr& Ismail, Amal. 2013. Markers of neural degeneration and regeneration in Down syndrome patients. The Egyptian Journal of Medical Human Genetics،Vol. 14, no. 1, pp.49-53.
https://search.emarefa.net/detail/BIM-358455
Modern Language Association (MLA)
Kurraa, Suhayr…[et al.]. Markers of neural degeneration and regeneration in Down syndrome patients. The Egyptian Journal of Medical Human Genetics Vol. 14, no. 1 (Jan. 2013), pp.49-53.
https://search.emarefa.net/detail/BIM-358455
American Medical Association (AMA)
Abd al-Majid, Iman Ihsan& Abd al-Salam, Ikram& Abd al-Latif, Duaa M.& Kurraa, Suhayr& Ismail, Amal. Markers of neural degeneration and regeneration in Down syndrome patients. The Egyptian Journal of Medical Human Genetics. 2013. Vol. 14, no. 1, pp.49-53.
https://search.emarefa.net/detail/BIM-358455
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 52-53
Record ID
BIM-358455