Possible association of interleukin-1beta (-511CT) and interleukin-6 (-174GC) gene polymorphisms with atherosclerosis in end stage renal disease egyptian patients on maintenance haemodialysis
المؤلفون المشاركون
Khalil, Jihan Ibrahim
Qandil, Muna Husayn
Magour, Jihan Mahmud
Maharem, Dalia Ali
Nomair, Azhar Muhammad
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 14، العدد 3 (31 يوليو/تموز 2013)، ص ص. 267-275، 9ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2013-07-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
In end stage renal disease, inflammation is considered a critical regulator of atherosclerotic plaque formation and progression, to which many dialysis and non-dialysis-related factors may contribute.
Since circulating inflammatory cytokine levels vary inter-individually, one may speculate that genetic factors, such as polymorphisms in genes encoding them, may be involved in determining the individual inflammatory reaction in response to a given insult.
The present work aimed to study interleukin-1B (-511C / T), and interleukin-6 (-174G / C) gene polymorphisms and their possible association with atherosclerosis in Egyptian patients with end stage renal disease on maintenance haemodialysis.
The present study was conducted on 100 Egyptian subjects, the control group (n = 30) and the patient group (n = 70) with end stage renal disease on maintenance haemodialysis which were further subdivided into two subgroups with (n = 33) and without atherosclerosis (n = 37) as evidenced by CIMT, ECG ischaemic changes, cerebrovascular insufficiency (CVI), and peripheral vascular insufficiency (PVI).
All studied subjects were subjected to detailed history taking, routine laboratory investigations and molecular studies including detection of IL- 1B (-511C / T) and IL-6 (-174G / C) gene polymorphisms using the Polymerase chain reaction / Restriction fragment length polymorphism (PCR / RFLP) technique.
The genotype distribution and allele frequency of IL-1B (-511C / T) and IL-6 (-174G / C) showed no statistical significant difference among the studied groups.
To conclude the development of atherosclerosis among Egyptian patients on maintenance haemodialysis cannot be attributed to these two gene polymorphisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qandil, Muna Husayn& Magour, Jihan Mahmud& Khalil, Jihan Ibrahim& Maharem, Dalia Ali& Nomair, Azhar Muhammad. 2013. Possible association of interleukin-1beta (-511CT) and interleukin-6 (-174GC) gene polymorphisms with atherosclerosis in end stage renal disease egyptian patients on maintenance haemodialysis. The Egyptian Journal of Medical Human Genetics،Vol. 14, no. 3, pp.267-275.
https://search.emarefa.net/detail/BIM-360739
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qandil, Muna Husayn…[et al.]. Possible association of interleukin-1beta (-511CT) and interleukin-6 (-174GC) gene polymorphisms with atherosclerosis in end stage renal disease egyptian patients on maintenance haemodialysis. The Egyptian Journal of Medical Human Genetics Vol. 14, no. 3 (Jul. 2013), pp.267-275.
https://search.emarefa.net/detail/BIM-360739
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qandil, Muna Husayn& Magour, Jihan Mahmud& Khalil, Jihan Ibrahim& Maharem, Dalia Ali& Nomair, Azhar Muhammad. Possible association of interleukin-1beta (-511CT) and interleukin-6 (-174GC) gene polymorphisms with atherosclerosis in end stage renal disease egyptian patients on maintenance haemodialysis. The Egyptian Journal of Medical Human Genetics. 2013. Vol. 14, no. 3, pp.267-275.
https://search.emarefa.net/detail/BIM-360739
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 273-275
رقم السجل
BIM-360739
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر