Possible association of interleukin-1beta (-511CT) and interleukin-6 (-174GC) gene polymorphisms with atherosclerosis in end stage renal disease egyptian patients on maintenance haemodialysis
Joint Authors
Khalil, Jihan Ibrahim
Qandil, Muna Husayn
Magour, Jihan Mahmud
Maharem, Dalia Ali
Nomair, Azhar Muhammad
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 14, Issue 3 (31 Jul. 2013), pp.267-275, 9 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2013-07-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
In end stage renal disease, inflammation is considered a critical regulator of atherosclerotic plaque formation and progression, to which many dialysis and non-dialysis-related factors may contribute.
Since circulating inflammatory cytokine levels vary inter-individually, one may speculate that genetic factors, such as polymorphisms in genes encoding them, may be involved in determining the individual inflammatory reaction in response to a given insult.
The present work aimed to study interleukin-1B (-511C / T), and interleukin-6 (-174G / C) gene polymorphisms and their possible association with atherosclerosis in Egyptian patients with end stage renal disease on maintenance haemodialysis.
The present study was conducted on 100 Egyptian subjects, the control group (n = 30) and the patient group (n = 70) with end stage renal disease on maintenance haemodialysis which were further subdivided into two subgroups with (n = 33) and without atherosclerosis (n = 37) as evidenced by CIMT, ECG ischaemic changes, cerebrovascular insufficiency (CVI), and peripheral vascular insufficiency (PVI).
All studied subjects were subjected to detailed history taking, routine laboratory investigations and molecular studies including detection of IL- 1B (-511C / T) and IL-6 (-174G / C) gene polymorphisms using the Polymerase chain reaction / Restriction fragment length polymorphism (PCR / RFLP) technique.
The genotype distribution and allele frequency of IL-1B (-511C / T) and IL-6 (-174G / C) showed no statistical significant difference among the studied groups.
To conclude the development of atherosclerosis among Egyptian patients on maintenance haemodialysis cannot be attributed to these two gene polymorphisms.
American Psychological Association (APA)
Qandil, Muna Husayn& Magour, Jihan Mahmud& Khalil, Jihan Ibrahim& Maharem, Dalia Ali& Nomair, Azhar Muhammad. 2013. Possible association of interleukin-1beta (-511CT) and interleukin-6 (-174GC) gene polymorphisms with atherosclerosis in end stage renal disease egyptian patients on maintenance haemodialysis. The Egyptian Journal of Medical Human Genetics،Vol. 14, no. 3, pp.267-275.
https://search.emarefa.net/detail/BIM-360739
Modern Language Association (MLA)
Qandil, Muna Husayn…[et al.]. Possible association of interleukin-1beta (-511CT) and interleukin-6 (-174GC) gene polymorphisms with atherosclerosis in end stage renal disease egyptian patients on maintenance haemodialysis. The Egyptian Journal of Medical Human Genetics Vol. 14, no. 3 (Jul. 2013), pp.267-275.
https://search.emarefa.net/detail/BIM-360739
American Medical Association (AMA)
Qandil, Muna Husayn& Magour, Jihan Mahmud& Khalil, Jihan Ibrahim& Maharem, Dalia Ali& Nomair, Azhar Muhammad. Possible association of interleukin-1beta (-511CT) and interleukin-6 (-174GC) gene polymorphisms with atherosclerosis in end stage renal disease egyptian patients on maintenance haemodialysis. The Egyptian Journal of Medical Human Genetics. 2013. Vol. 14, no. 3, pp.267-275.
https://search.emarefa.net/detail/BIM-360739
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 273-275
Record ID
BIM-360739