The effects of the administration of hydrocortisone sodium succinate on the periodontium of albino rats : experimental histochimical study

الملخص EN

The effects of the administration of cortisone upon numerous body tissues has been described, changes in the periodontal tissue of developing albino rats (newborn) histochemically have not been described.

A study was therefore, under taken to investigate the effect of administration of cortisone upon the periodontal ligament tissues.

Materials and methods: Experimental animals (new born rats, their age 10, 19,25 days old) were treated by cortisone, saggital section were stained by alcian blue and H&E stains.

Results: Hydrocortisone sodium succinate affect that periodontal tissue development and this drug inhibit and delay the synthesise of GAGs (glycosaminoglycans) till aged 25 post natal (p.n.).

Conclusion: The periodontal membrane in the treated groups is affected (delay in the GAGs synthesis) by the hydrocortisone sodium succinate drug administration