Synthesis of some substituted multinuclear 1,3,4-oxadiazoles and 1,3,4-thiadiazoles

المؤلفون المشاركون

Dawud, Khalid M.
Isa, Muhammad A. A.

المصدر

National Journal of Chemistry

العدد

المجلد 2005، العدد 19 (30 سبتمبر/أيلول 2005)، ص ص. 405-411، 7ص.

الناشر

جامعة بابل كلية العلوم

تاريخ النشر

2005-09-30

دولة النشر

العراق

عدد الصفحات

7

التخصصات الرئيسية

الكيمياء

الموضوعات

الملخص EN

The synthesis of multinuclear heterocyclic system containing substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole ring was achieved from suitable esters which were converted to the corresponding acid hydrazides by their reaction with hydrazine hydrate in ethanol.

The treatment of acid hydrazide with phosgene or with carbon disulfide gave substituted oxadiazole-2-one or 2-thiol respectively.

5-Phenyl-1,3,4-oxadiazole-2-thiol was treated with 2-chloro-5-phenyl-1,3,4-thiadiazole in ethanolic potassium hydroxide solution to give (5-phenyl-1,3,4-oxadiazol-2-yl) (5-phenyl-1,3,4-thiadiazol-2-yl) sulfide, whereas the reaction of 1-[5-(4-aminophenyl)-1,3,4-oxadiazol-2-yl] hydrazine and 5-(4-aminophenyl)-2-amino-1,3,4-thiadiazole with 5-phenyl-2-chloro-1,3,4-thiadiazole gave 1-[5-{4-N-(5-phenyl-1,3,4-thiadiazol-2-yl) aminophenyl}-1,3,4-oxadiazole-2-yl] 2-[5- phenyl-1,3,4-thiadiazol-2-yl] hydrazine and [5-{4-N-(5-phenyl-1,3,4-thiadiazole-2-yl)aminophenyl}-1,3,4-thiadiazol-2-yl] [5-phenyl-1,3,4-thiadiazol-2-yl] amine respectively.

The structure of synthesized compounds was established by physical and spectral means.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Dawud, Khalid M.& Isa, Muhammad A. A.. 2005. Synthesis of some substituted multinuclear 1,3,4-oxadiazoles and 1,3,4-thiadiazoles. National Journal of Chemistry،Vol. 2005, no. 19, pp.405-411.
https://search.emarefa.net/detail/BIM-362377

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Dawud, Khalid M.& Isa, Muhammad A. A.. Synthesis of some substituted multinuclear 1,3,4-oxadiazoles and 1,3,4-thiadiazoles. National Journal of Chemistry No. 19 (2005), pp.405-411.
https://search.emarefa.net/detail/BIM-362377

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Dawud, Khalid M.& Isa, Muhammad A. A.. Synthesis of some substituted multinuclear 1,3,4-oxadiazoles and 1,3,4-thiadiazoles. National Journal of Chemistry. 2005. Vol. 2005, no. 19, pp.405-411.
https://search.emarefa.net/detail/BIM-362377

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 411

رقم السجل

BIM-362377