Synthesis of some substituted multinuclear 1,3,4-oxadiazoles and 1,3,4-thiadiazoles
Joint Authors
Dawud, Khalid M.
Isa, Muhammad A. A.
Source
Issue
Vol. 2005, Issue 19 (30 Sep. 2005), pp.405-411, 7 p.
Publisher
University of Babylon College of Sciences
Publication Date
2005-09-30
Country of Publication
Iraq
No. of Pages
7
Main Subjects
Topics
Abstract EN
The synthesis of multinuclear heterocyclic system containing substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole ring was achieved from suitable esters which were converted to the corresponding acid hydrazides by their reaction with hydrazine hydrate in ethanol.
The treatment of acid hydrazide with phosgene or with carbon disulfide gave substituted oxadiazole-2-one or 2-thiol respectively.
5-Phenyl-1,3,4-oxadiazole-2-thiol was treated with 2-chloro-5-phenyl-1,3,4-thiadiazole in ethanolic potassium hydroxide solution to give (5-phenyl-1,3,4-oxadiazol-2-yl) (5-phenyl-1,3,4-thiadiazol-2-yl) sulfide, whereas the reaction of 1-[5-(4-aminophenyl)-1,3,4-oxadiazol-2-yl] hydrazine and 5-(4-aminophenyl)-2-amino-1,3,4-thiadiazole with 5-phenyl-2-chloro-1,3,4-thiadiazole gave 1-[5-{4-N-(5-phenyl-1,3,4-thiadiazol-2-yl) aminophenyl}-1,3,4-oxadiazole-2-yl] 2-[5- phenyl-1,3,4-thiadiazol-2-yl] hydrazine and [5-{4-N-(5-phenyl-1,3,4-thiadiazole-2-yl)aminophenyl}-1,3,4-thiadiazol-2-yl] [5-phenyl-1,3,4-thiadiazol-2-yl] amine respectively.
The structure of synthesized compounds was established by physical and spectral means.
American Psychological Association (APA)
Dawud, Khalid M.& Isa, Muhammad A. A.. 2005. Synthesis of some substituted multinuclear 1,3,4-oxadiazoles and 1,3,4-thiadiazoles. National Journal of Chemistry،Vol. 2005, no. 19, pp.405-411.
https://search.emarefa.net/detail/BIM-362377
Modern Language Association (MLA)
Dawud, Khalid M.& Isa, Muhammad A. A.. Synthesis of some substituted multinuclear 1,3,4-oxadiazoles and 1,3,4-thiadiazoles. National Journal of Chemistry No. 19 (2005), pp.405-411.
https://search.emarefa.net/detail/BIM-362377
American Medical Association (AMA)
Dawud, Khalid M.& Isa, Muhammad A. A.. Synthesis of some substituted multinuclear 1,3,4-oxadiazoles and 1,3,4-thiadiazoles. National Journal of Chemistry. 2005. Vol. 2005, no. 19, pp.405-411.
https://search.emarefa.net/detail/BIM-362377
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 411
Record ID
BIM-362377