Synthesis, characterization and biological activity of some mannich bases

مقدم أطروحة جامعية

al-Zubayr, Halah Ismail Muhammad

مشرف أطروحة جامعية

Fadul, Muhammad Himmat
Abd al-Karim, Muhammad

الجامعة

جامعة أم درمان الإسلامية

الكلية

كلية العلوم و التقانة

القسم الأكاديمي

قسم الكيمياء

دولة الجامعة

السودان

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2012

الملخص الإنجليزي

Ten Mannich bases were synthesized via a general protocol involving the condensation of an active hydrogen compound with different primary and secondary amines in presence of formalin.Thus the following targeted series of ketonic and phenolic Mannich adducts were synthesized:-- 2-acetamidomethyl-4-acetamidophenol (I) N,N-[(5-acatamido-hydroxy)benzyl]acetamide (II) - N-[(5-acatamido-2-hydroxy)benzyl]methylamine (III) -N,N-[(5-acatamido-2-hydroxy)benzyl]methylamine (IV) - N,N-[(5-acatamido-2-hydroxy)benzyl]ethylamine (V) - N-[(5-acatamido-2-hydroxy)benzyl]ethylamine (VI) -N-[(5-acatamidohydroxy)benzylmethylanilinomethylamine (VII) -1-phenyl-3-(pyrrolidin-1-yl)propan-1one (VIII) -1-phenyl-3-(dimethylamino)propan1-one (IX) -2-pyrrolidinomethylcyclohexanone (X).

The structures of the targeted molecules were deduced on the basis of their spectral data (UV, IR,NMR and MS).

The series of targeted molecules were screened for their antibacterial and antifungal potential and significant activity was observed for most of the Mannich bases.

Hence these Mannich adducts are suitable molecules for further optimization.

التخصصات الرئيسية

الكيمياء

الموضوعات

• الكيمياء العضوية الحيوية

عدد الصفحات

86

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-363148