Comparative evaluation of physical and pharmaceutical properties of treated guar, non treated guar and xanthan gums

مقدم أطروحة جامعية

al-Sayyid, Najla Abd al-Ghani

مشرف أطروحة جامعية

Nur, Abu Bakr Uthman M.
Mustafa, Asim Faruq

الجامعة

جامعة أم درمان الإسلامية

الكلية

كلية الصيدلة

دولة الجامعة

السودان

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2010

الملخص الإنجليزي

In this study, guar gum was treated thermally utilizing a 3² full factorial design where both temperature and time were investigated for their impact on the physical performance of the treated guar.

The result has pointed to the effect of both factors on the viscosity of the produced guar gum where unexpected increase in viscosity at temperature ranged 50-70°C was revealed and attributed to the solubilisation of the polymer resulting from temperature elevation and timing.

Compared to non treated guar and xanthan gums, treated guar gum revealed an improved viscosity, swelling ability and compressibility features.

Moreover, tablet formulations composed of treated guar gum showed improved flowability, accepted tablet hardness and accepted friability more than those associated with non treated guar and xanthan gums.

Furthermore, it has been shown that the release of loaded drugs from treated guar gum tablets was the fastest among other polymers owing to the low viscosity and swelling capacity of the treated guar gum which result in delay in the formation of gel layer that control the drug release from such type of tablet formulations.

التخصصات الرئيسية

علم الصيدلة

الموضوعات

• الأدوية

عدد الصفحات

50

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-364023