Comparative evaluation of physical and pharmaceutical properties of treated guar, non treated guar and xanthan gums

Dissertant

al-Sayyid, Najla Abd al-Ghani

Thesis advisor

Nur, Abu Bakr Uthman M.
Mustafa, Asim Faruq

University

Omdurman Islamic University

Faculty

Faculty of Pharmacy

University Country

Sudan

Degree

Master

Degree Date

2010

English Abstract

In this study, guar gum was treated thermally utilizing a 3² full factorial design where both temperature and time were investigated for their impact on the physical performance of the treated guar.

The result has pointed to the effect of both factors on the viscosity of the produced guar gum where unexpected increase in viscosity at temperature ranged 50-70°C was revealed and attributed to the solubilisation of the polymer resulting from temperature elevation and timing.

Compared to non treated guar and xanthan gums, treated guar gum revealed an improved viscosity, swelling ability and compressibility features.

Moreover, tablet formulations composed of treated guar gum showed improved flowability, accepted tablet hardness and accepted friability more than those associated with non treated guar and xanthan gums.

Furthermore, it has been shown that the release of loaded drugs from treated guar gum tablets was the fastest among other polymers owing to the low viscosity and swelling capacity of the treated guar gum which result in delay in the formation of gel layer that control the drug release from such type of tablet formulations.

Main Subjects

Pharmacology

Topics

• Drugs

No. of Pages

50

Table of Contents

• APA
• MLA
• AMA

Language

English

Data Type

Arab Theses

Record ID

BIM-364023