Extraction, formulation and evaluation of Grewia tenax (Forssk.) fruits as effervescent tablets for treatment of iron deficiency anemia
مقدم أطروحة جامعية
Ibrahim, Yusuf Hamid al-Nil Yusuf
مشرف أطروحة جامعية
Abd al-Karim, Abd al-Karim Muhammad
Khalid, Hasan al-Subki
الجامعة
جامعة أم درمان الإسلامية
الكلية
كلية الصيدلة
دولة الجامعة
السودان
الدرجة العلمية
ماجستير
تاريخ الدرجة العلمية
2012
الملخص الإنجليزي
-The use of Grewia tenax fruits as dietary supplement is widespread, especially throughout the west and south of Sudan and mainly used in traditional medicine by tribes that live in these areas of Sudan for treatment of typhoid fever, malaria, iron deficiency anemia, and malnutrition diseases for long time, as well as cold beverage (general tonic).
The aim of this study is to find an easy and reproducible method of extraction to the fruits of G.
tenax in a similar manner of traditional extraction method and to standardize the extract that selected for formulation into suitable dosage for children and elder persons that can be easily administered (effervescent tablets) using thin layer chromatography (TLC), Infrared (IR) and Ultra-Violet (UV) spectrometry.
The selected extract (maceration method using ethanol 80%) for formulation reveals the highest yield value and iron content compared to other extracts. Two -step wet granulation method was the method of choice to formulate both formulae in reproducible manner because the extract had semi-solid consistency due to high content of carbohydrates this makes the drying process using heat to dry the extract impossible.
Microcrystalline cellulose was added to both formulae to adsorb the excess moisture and to facilitate the disintegration of tablets, where as lactose had less efficiency to adsorb the moisture but provide additional palatability to tablets.
The produced tablets of both formulae showed good quality and passed all quality control tests that subjected.
التخصصات الرئيسية
الموضوعات
عدد الصفحات
155
قائمة المحتويات
Table of contents.
Abstract.
Chapter One : Introduction and literature review.
Chapter Two : Pharmaceutical and technical aspects.
Chapter Three : Objectives of the study.
Chapter Four : Materials and methods.
Chapter Five : Results.
Chapter Six : Discussion, conclusion and recommendations.
References.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ibrahim, Yusuf Hamid al-Nil Yusuf. (2012). Extraction, formulation and evaluation of Grewia tenax (Forssk.) fruits as effervescent tablets for treatment of iron deficiency anemia. (Master's theses Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-364323
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ibrahim, Yusuf Hamid al-Nil Yusuf. Extraction, formulation and evaluation of Grewia tenax (Forssk.) fruits as effervescent tablets for treatment of iron deficiency anemia. (Master's theses Theses and Dissertations Master). Omdurman Islamic University. (2012).
https://search.emarefa.net/detail/BIM-364323
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ibrahim, Yusuf Hamid al-Nil Yusuf. (2012). Extraction, formulation and evaluation of Grewia tenax (Forssk.) fruits as effervescent tablets for treatment of iron deficiency anemia. (Master's theses Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-364323
لغة النص
الإنجليزية
نوع البيانات
رسائل جامعية
رقم السجل
BIM-364323
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر