Extraction, formulation and evaluation of Grewia tenax (Forssk.) fruits as effervescent tablets for treatment of iron deficiency anemia
Dissertant
Ibrahim, Yusuf Hamid al-Nil Yusuf
Thesis advisor
Abd al-Karim, Abd al-Karim Muhammad
Khalid, Hasan al-Subki
University
Omdurman Islamic University
Faculty
Faculty of Pharmacy
University Country
Sudan
Degree
Master
Degree Date
2012
English Abstract
-The use of Grewia tenax fruits as dietary supplement is widespread, especially throughout the west and south of Sudan and mainly used in traditional medicine by tribes that live in these areas of Sudan for treatment of typhoid fever, malaria, iron deficiency anemia, and malnutrition diseases for long time, as well as cold beverage (general tonic).
The aim of this study is to find an easy and reproducible method of extraction to the fruits of G.
tenax in a similar manner of traditional extraction method and to standardize the extract that selected for formulation into suitable dosage for children and elder persons that can be easily administered (effervescent tablets) using thin layer chromatography (TLC), Infrared (IR) and Ultra-Violet (UV) spectrometry.
The selected extract (maceration method using ethanol 80%) for formulation reveals the highest yield value and iron content compared to other extracts. Two -step wet granulation method was the method of choice to formulate both formulae in reproducible manner because the extract had semi-solid consistency due to high content of carbohydrates this makes the drying process using heat to dry the extract impossible.
Microcrystalline cellulose was added to both formulae to adsorb the excess moisture and to facilitate the disintegration of tablets, where as lactose had less efficiency to adsorb the moisture but provide additional palatability to tablets.
The produced tablets of both formulae showed good quality and passed all quality control tests that subjected.
Main Subjects
Topics
- Medical care
- Folklore
- Medicine
- Traditional medicine
- Iron deficiency anemia
- Alternative medicine
- Anthropological aspects
No. of Pages
155
Table of Contents
Table of contents.
Abstract.
Chapter One : Introduction and literature review.
Chapter Two : Pharmaceutical and technical aspects.
Chapter Three : Objectives of the study.
Chapter Four : Materials and methods.
Chapter Five : Results.
Chapter Six : Discussion, conclusion and recommendations.
References.
American Psychological Association (APA)
Ibrahim, Yusuf Hamid al-Nil Yusuf. (2012). Extraction, formulation and evaluation of Grewia tenax (Forssk.) fruits as effervescent tablets for treatment of iron deficiency anemia. (Master's theses Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-364323
Modern Language Association (MLA)
Ibrahim, Yusuf Hamid al-Nil Yusuf. Extraction, formulation and evaluation of Grewia tenax (Forssk.) fruits as effervescent tablets for treatment of iron deficiency anemia. (Master's theses Theses and Dissertations Master). Omdurman Islamic University. (2012).
https://search.emarefa.net/detail/BIM-364323
American Medical Association (AMA)
Ibrahim, Yusuf Hamid al-Nil Yusuf. (2012). Extraction, formulation and evaluation of Grewia tenax (Forssk.) fruits as effervescent tablets for treatment of iron deficiency anemia. (Master's theses Theses and Dissertations Master). Omdurman Islamic University, Sudan
https://search.emarefa.net/detail/BIM-364323
Language
English
Data Type
Arab Theses
Record ID
BIM-364323
