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The influence of histamine H1-receptor on liver functions in immunized rabbits
المؤلفون المشاركون
Shahid, Muhammad
Tripathi, Trivendra
Khan, Haris M.
Khan, Rahat Ali
Siddiqi, Mashiatullah
Mahdi, Abbas Ali
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 18، العدد 4 (31 ديسمبر/كانون الأول 2011)، ص ص. 411-418، 8ص.
الناشر
تاريخ النشر
2011-12-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
This study was designed to investigate the functional roles of histamine and histamine H1-receptor agonist and antagonist in the development of liver function impairment in immunized rabbits.
The study comprised of six groups containing 18 rabbits each.
Group III–VI received histamine (100 lg / kg, s.c.), H1R-agonist (HTMT, 10 lg / kg, s.c.), H1R-antagonist (pheniramine, 10 mg / kg, i.m.), and H1R-antagonist (pheniramine, 10 mg / kg, i.m.) plus histamine (100 lg / kg, s.c.), respectively, b.i.d.
for 10 days.
Group I (negative control) and group II (positive control) received sterile distilled water intramuscularly b.i.d.
for 10 days.
Groups II–VI were immunized on day 3 with intravenous injection of SRBC (1 • 109 cells / ml).
Blood samples were collected on pre-immunization day 0, as well as on days 7-, 14-, 21-, 28-, and 58-post-immunization.
Biochemical parameters AST, ALT, alkaline phosphatase and bilirubin [total bilirubin (TB), direct bilirubin (DB), and indirect bilirubin (IB)] were determined.
On each experimental day, the mean values of serum enzymes and bilirubin in group I and group II showed no significant changes while in group III, IV, V, and VI, these enzymes and bilirubin levels showed significant changes (p < 0.05), when compared with their experimental values within the group.
The levels of serum enzymes and bilirubin showed significant difference (p < 0.05) in group III, IV, V, and VI on each experimental day, when compared with the corresponding values of each other, and also compared with the corresponding values of group I and II.
Histamine, HTMT, pheniramine, and combination of histamine + pheniramine cause hepatic function impairment in terms of altered serum enzymes and bilirubin levels.
The present findings suggest that HTMT causes moderate liver function impairment while others show mild impairment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tripathi, Trivendra& Shahid, Muhammad& Khan, Haris M.& Khan, Rahat Ali& Siddiqi, Mashiatullah& Mahdi, Abbas Ali. 2011. The influence of histamine H1-receptor on liver functions in immunized rabbits. Saudi Journal of Biological Sciences،Vol. 18, no. 4, pp.411-418.
https://search.emarefa.net/detail/BIM-364650
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tripathi, Trivendra…[et al.]. The influence of histamine H1-receptor on liver functions in immunized rabbits. Saudi Journal of Biological Sciences Vol. 18, no. 4 (2011), pp.411-418.
https://search.emarefa.net/detail/BIM-364650
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tripathi, Trivendra& Shahid, Muhammad& Khan, Haris M.& Khan, Rahat Ali& Siddiqi, Mashiatullah& Mahdi, Abbas Ali. The influence of histamine H1-receptor on liver functions in immunized rabbits. Saudi Journal of Biological Sciences. 2011. Vol. 18, no. 4, pp.411-418.
https://search.emarefa.net/detail/BIM-364650
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 417-418
رقم السجل
BIM-364650
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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