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Prognostic value of lymph node ratio in node-positive breast cancer in egyptian patients
المؤلفون المشاركون
Ibrahim, Muhammad A.
al-Khudari, Tawfiq R.
al-Sayyid, Hatata E.
Niyazi, Nirmin A.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 26، العدد 1 (31 مارس/آذار 2014)، ص ص. 31-35، 5ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2014-03-31
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Breast cancer in Egypt is the most common cancer among women and is the leading cause of cancer mortality.
Traditionally, axillary lymph node involvement is considered among the most important prognostic factors in breast cancer.
Nonetheless, accumulating evidence suggests that axillary lymph node ratio should be considered as an alternative to classical pN classification.
Materials and methods : We performed a retrospective analysis of patients with operable nodepositive breast cancer, to investigate the prognostic significance of axillary lymph node ratio.
Results : Five-hundred patients were considered eligible for the analysis.
Median follow-up was 35 months (95 % CI 32–37 months), the median disease-free survival (DFS) was 49 months (95 % CI, 46.4–52.2 months).
The classification of patients based on pN staging system failed to prognosticate DFS in the multivariate analysis.
Conversely, grade 3 tumors, and the intermediate (>0.20 to 60.65) and high (>0.65) LNR were the only variables that were independently associated with adverse DFS.
The overall survival (OS) in this series was 69 months (95 % CI 60–77).
Conclusion : The analysis of outcome of patients with early breast cancer in Egypt identified the adverse prognostic effects of high tumor grade, ER negativity and intermediate and high LNR on DFS.
If the utility of the LNR is validated in other studies, it may replace the use of absolute number of axillary lymph nodes.
ª 2013 Production and hosting by Elsevier B.V.
on behalf of National Cancer Institute, Cairo University.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Khudari, Tawfiq R.& Ibrahim, Muhammad A.& al-Sayyid, Hatata E.& Niyazi, Nirmin A.. 2014. Prognostic value of lymph node ratio in node-positive breast cancer in egyptian patients. Journal of the Egyptian National Cancer Institute،Vol. 26, no. 1, pp.31-35.
https://search.emarefa.net/detail/BIM-365245
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Khudari, Tawfiq R.…[et al.]. Prognostic value of lymph node ratio in node-positive breast cancer in egyptian patients. Journal of the Egyptian National Cancer Institute Vol. 26, no. 1 (2014), pp.31-35.
https://search.emarefa.net/detail/BIM-365245
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Khudari, Tawfiq R.& Ibrahim, Muhammad A.& al-Sayyid, Hatata E.& Niyazi, Nirmin A.. Prognostic value of lymph node ratio in node-positive breast cancer in egyptian patients. Journal of the Egyptian National Cancer Institute. 2014. Vol. 26, no. 1, pp.31-35.
https://search.emarefa.net/detail/BIM-365245
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 35
رقم السجل
BIM-365245
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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