Prognostic value of lymph node ratio in node-positive breast cancer in egyptian patients
Joint Authors
Ibrahim, Muhammad A.
al-Khudari, Tawfiq R.
al-Sayyid, Hatata E.
Niyazi, Nirmin A.
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 26, Issue 1 (31 Mar. 2014), pp.31-35, 5 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2014-03-31
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Breast cancer in Egypt is the most common cancer among women and is the leading cause of cancer mortality.
Traditionally, axillary lymph node involvement is considered among the most important prognostic factors in breast cancer.
Nonetheless, accumulating evidence suggests that axillary lymph node ratio should be considered as an alternative to classical pN classification.
Materials and methods : We performed a retrospective analysis of patients with operable nodepositive breast cancer, to investigate the prognostic significance of axillary lymph node ratio.
Results : Five-hundred patients were considered eligible for the analysis.
Median follow-up was 35 months (95 % CI 32–37 months), the median disease-free survival (DFS) was 49 months (95 % CI, 46.4–52.2 months).
The classification of patients based on pN staging system failed to prognosticate DFS in the multivariate analysis.
Conversely, grade 3 tumors, and the intermediate (>0.20 to 60.65) and high (>0.65) LNR were the only variables that were independently associated with adverse DFS.
The overall survival (OS) in this series was 69 months (95 % CI 60–77).
Conclusion : The analysis of outcome of patients with early breast cancer in Egypt identified the adverse prognostic effects of high tumor grade, ER negativity and intermediate and high LNR on DFS.
If the utility of the LNR is validated in other studies, it may replace the use of absolute number of axillary lymph nodes.
ª 2013 Production and hosting by Elsevier B.V.
on behalf of National Cancer Institute, Cairo University.
American Psychological Association (APA)
al-Khudari, Tawfiq R.& Ibrahim, Muhammad A.& al-Sayyid, Hatata E.& Niyazi, Nirmin A.. 2014. Prognostic value of lymph node ratio in node-positive breast cancer in egyptian patients. Journal of the Egyptian National Cancer Institute،Vol. 26, no. 1, pp.31-35.
https://search.emarefa.net/detail/BIM-365245
Modern Language Association (MLA)
al-Khudari, Tawfiq R.…[et al.]. Prognostic value of lymph node ratio in node-positive breast cancer in egyptian patients. Journal of the Egyptian National Cancer Institute Vol. 26, no. 1 (2014), pp.31-35.
https://search.emarefa.net/detail/BIM-365245
American Medical Association (AMA)
al-Khudari, Tawfiq R.& Ibrahim, Muhammad A.& al-Sayyid, Hatata E.& Niyazi, Nirmin A.. Prognostic value of lymph node ratio in node-positive breast cancer in egyptian patients. Journal of the Egyptian National Cancer Institute. 2014. Vol. 26, no. 1, pp.31-35.
https://search.emarefa.net/detail/BIM-365245
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 35
Record ID
BIM-365245