Irrigation of abdomen with imipenem solution decreases surgical site infections in patients with perforated appendicitis : a randomized clinical trial
المؤلفون المشاركون
Hesami, Muhammad Ali
Alipour, Hamid
Daylami, Hamid Nikoupour
Ahmadi, Alireza
Hijazi, Shahrzad Bazargan
Alipour, Bijan
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 4 (30 إبريل/نيسان 2014)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2014-04-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Perforated appendicitis is one of the most common causes of acute abdomen requiring emergent surgery for immediate appendectomy and peritoneal cavity irrigation; however, the efficacy of irrigation with antibiotic solutions is controversial.
Objectives : The aim of this study was to assess the efficacy of imipenem solution irrigation on post-operative surgical site infections (SSIs), hospital length of stay, and hospital costs.
We hypothesized that there would be lower rate of SSIs, a shorter hospital stay, and lower hospital cost in patients with perforated appendicitis who received peritoneal cavity irrigation with imipenem solution in comparison to their counterparts who received irrigation with normal saline.
Patients and Methods : In this randomized single-blind parallel-group clinical trial, we enrolled 90 patients with perforated appendicitis with 12-50 years of age and randomly allocated them into experimental group (n = 45) and control group (n = 45).
The control group received peritoneal irrigation with normal saline (0.9 %) and experimental group underwent peritoneal irrigation with imipenem solution (1 mg / mL).
All surgical procedures were performed in Imam Reza Hospital of Kermanshah University of Medical Sciences.
The study primary outcome was surgical site infections (including wound infection and abdominal abscess) and the secondary outcomes were length of hospital stay and hospital cost.
Chi-squared and t-tests were used to analyze the study data.
Results : Imipenem solution irrigation was associated with significant clinical improvement at one-month follow-up.
The experimental group presented with significantly lower rate of SSIs and shorter length of hospital stay.
The experimental group had lower rate of SSIs compared to the control group (4.4 % vs.
22.2 %, respectively) (p = 0.013).
The duration of hospital stay was nearly one day longer in control group (5.84 ± 2.58 days) vs.
experimental group (4.91 ± 1.29 days) (P = 0.034), and hospital costs were $50 lower in experimental group ($ 500 ± $ 292) vs.
control group ($ 450 ± $ 170) (P = 0.281).
Conclusions : The study findings revealed that peritoneal lavage with imipenem solution (1 mg / mL) decreases the rate of post-operative SSIs in patients with perforated appendicitis in comparison to patients irrigated with normal saline alone.
These patients also had shorter hospital stay, and lower hospital costs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hesami, Muhammad Ali& Alipour, Hamid& Daylami, Hamid Nikoupour& Alipour, Bijan& Hijazi, Shahrzad Bazargan& Ahmadi, Alireza. 2014. Irrigation of abdomen with imipenem solution decreases surgical site infections in patients with perforated appendicitis : a randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 16, no. 4, pp.1-6.
https://search.emarefa.net/detail/BIM-366168
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alipour, Bijan…[et al.]. Irrigation of abdomen with imipenem solution decreases surgical site infections in patients with perforated appendicitis : a randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 16, no. 4 (Apr. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-366168
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hesami, Muhammad Ali& Alipour, Hamid& Daylami, Hamid Nikoupour& Alipour, Bijan& Hijazi, Shahrzad Bazargan& Ahmadi, Alireza. Irrigation of abdomen with imipenem solution decreases surgical site infections in patients with perforated appendicitis : a randomized clinical trial. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 4, pp.1-6.
https://search.emarefa.net/detail/BIM-366168
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 6
رقم السجل
BIM-366168
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر