Irrigation of abdomen with imipenem solution decreases surgical site infections in patients with perforated appendicitis : a randomized clinical trial
Joint Authors
Hesami, Muhammad Ali
Alipour, Hamid
Daylami, Hamid Nikoupour
Ahmadi, Alireza
Hijazi, Shahrzad Bazargan
Alipour, Bijan
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 4 (30 Apr. 2014), pp.1-6, 6 p.
Publisher
Publication Date
2014-04-30
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Perforated appendicitis is one of the most common causes of acute abdomen requiring emergent surgery for immediate appendectomy and peritoneal cavity irrigation; however, the efficacy of irrigation with antibiotic solutions is controversial.
Objectives : The aim of this study was to assess the efficacy of imipenem solution irrigation on post-operative surgical site infections (SSIs), hospital length of stay, and hospital costs.
We hypothesized that there would be lower rate of SSIs, a shorter hospital stay, and lower hospital cost in patients with perforated appendicitis who received peritoneal cavity irrigation with imipenem solution in comparison to their counterparts who received irrigation with normal saline.
Patients and Methods : In this randomized single-blind parallel-group clinical trial, we enrolled 90 patients with perforated appendicitis with 12-50 years of age and randomly allocated them into experimental group (n = 45) and control group (n = 45).
The control group received peritoneal irrigation with normal saline (0.9 %) and experimental group underwent peritoneal irrigation with imipenem solution (1 mg / mL).
All surgical procedures were performed in Imam Reza Hospital of Kermanshah University of Medical Sciences.
The study primary outcome was surgical site infections (including wound infection and abdominal abscess) and the secondary outcomes were length of hospital stay and hospital cost.
Chi-squared and t-tests were used to analyze the study data.
Results : Imipenem solution irrigation was associated with significant clinical improvement at one-month follow-up.
The experimental group presented with significantly lower rate of SSIs and shorter length of hospital stay.
The experimental group had lower rate of SSIs compared to the control group (4.4 % vs.
22.2 %, respectively) (p = 0.013).
The duration of hospital stay was nearly one day longer in control group (5.84 ± 2.58 days) vs.
experimental group (4.91 ± 1.29 days) (P = 0.034), and hospital costs were $50 lower in experimental group ($ 500 ± $ 292) vs.
control group ($ 450 ± $ 170) (P = 0.281).
Conclusions : The study findings revealed that peritoneal lavage with imipenem solution (1 mg / mL) decreases the rate of post-operative SSIs in patients with perforated appendicitis in comparison to patients irrigated with normal saline alone.
These patients also had shorter hospital stay, and lower hospital costs.
American Psychological Association (APA)
Hesami, Muhammad Ali& Alipour, Hamid& Daylami, Hamid Nikoupour& Alipour, Bijan& Hijazi, Shahrzad Bazargan& Ahmadi, Alireza. 2014. Irrigation of abdomen with imipenem solution decreases surgical site infections in patients with perforated appendicitis : a randomized clinical trial. Iranian Red Crescent Medical Journal،Vol. 16, no. 4, pp.1-6.
https://search.emarefa.net/detail/BIM-366168
Modern Language Association (MLA)
Alipour, Bijan…[et al.]. Irrigation of abdomen with imipenem solution decreases surgical site infections in patients with perforated appendicitis : a randomized clinical trial. Iranian Red Crescent Medical Journal Vol. 16, no. 4 (Apr. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-366168
American Medical Association (AMA)
Hesami, Muhammad Ali& Alipour, Hamid& Daylami, Hamid Nikoupour& Alipour, Bijan& Hijazi, Shahrzad Bazargan& Ahmadi, Alireza. Irrigation of abdomen with imipenem solution decreases surgical site infections in patients with perforated appendicitis : a randomized clinical trial. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 4, pp.1-6.
https://search.emarefa.net/detail/BIM-366168
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6
Record ID
BIM-366168