Antileishmanial activity of some Sudanese medicinal plants

مقدم أطروحة جامعية

Zarruq, al-Walid al-Amin Hasan

مشرف أطروحة جامعية

al-Tuhami, Mahjub Sharif
Musa, Ahmad M.

الجامعة

جامعة أم درمان الإسلامية

الكلية

كلية الصيدلة

دولة الجامعة

السودان

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2011

الملخص الإنجليزي

In this study petroleum ether, chloroform and methanol extracts of eleven plants were investigated for in vitro antileishamanial activity against Leishmaniadonovanipromastigotes at a concentration of 1mg / ml.

Most of the plants gave good results in one or more than one extract.

Xanthium brasilicumwas selected for study in details according to its high activity.

N-hexane extract exhibited the highest activity ( >50 % inhibition at 5μg/ml) out of six successive extracts of plant leaves, followed by petroleum ether, and chloroform extracts.

N-hexane and chloroform total extracts were found to be less active than n-hexane successive crude extract.

When n-hexane successive extract was fractionated to fourteen fractions, two of them, namely fractions 10 and 11 were found to be active, but with less activity than the original crude extract.

Compounds A & B, isolated from petroleum ether extract and n-hexane extract respectively, co-chromatography proved that they appeared as one compound, but infra-red spectroscopy proved that they were probably isomers.

Compound B was very active against Leishmaiapromastigotes (> 50 % inhibition at 3.5 μg / ml).

The activity of compound B against intracellular amastigote was good, but unfortunately toxic to the host cells.

Compound B was identified tentatively using spectroscopic methods as : (2E)-methyl 3-((1E, 4E)-7- methyl-4-(2-oxopropylidene) cyclohept-1-enyl) acrylate.

Phytochemical screening of X.

brasilicumleaves revealed the presence of akaloids, saponins, flavonoids and tannins, while cardiacglycosides, anthraquinones and cyanogenetic glycosides were absent.

التخصصات الرئيسية

علم الصيدلة

الموضوعات

• النباتات الطبية
• داء الليشمانيات
• الأدوية
• السودان

عدد الصفحات

127

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-367691