Azotemia protects the brain from osmotic demyelination on rapid correction of hyponatremia
المؤلفون المشاركون
Ahmad, Ijaz
Dhrolia, Murtada F.
Akhtar, Sayyid F.
Naqvi, Anwar
Rizvi, Adib
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 25، العدد 3 (30 يونيو/حزيران 2014)، ص ص. 558-566، 9ص.
الناشر
تاريخ النشر
2014-06-30
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Osmotic demyelination syndrome (ODS) is a dreadful, irreversible and wellrecognized clinical entity that classically occurs after rapid correction of hyponatremia.
However, it has been observed that when hyponatremia is rapidly corrected in azotemic patients by hemodialysis (HD), patients do not necessarily develop ODS.
We studied the effect of inadvertent rapid correction of hyponatremia with HD in patients with azotemia.
Fifty-two azotemic patients, who underwent HD at the Sindh Institute of Urology and Transplantation, having pre-HD serum sodium level < 125 mEq / L and post-HD serum sodium levels that increased by ≥ 12 mEq / L from their pre-dialysis level, were studied.
Serum sodium was analyzed before and within 24 h after a HD session.
HD was performed using bicarbonate solution, with the sodium concentration being 140 meq / L.
The duration of the dialysis session was based on the discretion of the treating nephrologist.
Patients were examined for any neurological symptoms or signs before and after HD and for up to two weeks.
Magnetic resonance imaging was performed in required cases.
None of the 52 patients with azotemia, despite inadvertent rapid correction of hyponatremia with HD, developed ODS.
This study suggests that patients with azotemia do not develop ODS on rapid correction of hyponatremia by HD, which suggests a possible protective role of azotemia on the brain from osmotic demyelination.
However, the mechanism by which azotemia protects the brain from demyelination in humans is largely hypothetical and further studies are needed to answer this question.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dhrolia, Murtada F.& Akhtar, Sayyid F.& Ahmad, Ijaz& Naqvi, Anwar& Rizvi, Adib. 2014. Azotemia protects the brain from osmotic demyelination on rapid correction of hyponatremia. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 3, pp.558-566.
https://search.emarefa.net/detail/BIM-370907
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dhrolia, Murtada F.…[et al.]. Azotemia protects the brain from osmotic demyelination on rapid correction of hyponatremia. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 3 (2014), pp.558-566.
https://search.emarefa.net/detail/BIM-370907
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dhrolia, Murtada F.& Akhtar, Sayyid F.& Ahmad, Ijaz& Naqvi, Anwar& Rizvi, Adib. Azotemia protects the brain from osmotic demyelination on rapid correction of hyponatremia. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 3, pp.558-566.
https://search.emarefa.net/detail/BIM-370907
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 565-566
رقم السجل
BIM-370907
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر