Azotemia protects the brain from osmotic demyelination on rapid correction of hyponatremia
Joint Authors
Ahmad, Ijaz
Dhrolia, Murtada F.
Akhtar, Sayyid F.
Naqvi, Anwar
Rizvi, Adib
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 25, Issue 3 (30 Jun. 2014), pp.558-566, 9 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2014-06-30
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract EN
Osmotic demyelination syndrome (ODS) is a dreadful, irreversible and wellrecognized clinical entity that classically occurs after rapid correction of hyponatremia.
However, it has been observed that when hyponatremia is rapidly corrected in azotemic patients by hemodialysis (HD), patients do not necessarily develop ODS.
We studied the effect of inadvertent rapid correction of hyponatremia with HD in patients with azotemia.
Fifty-two azotemic patients, who underwent HD at the Sindh Institute of Urology and Transplantation, having pre-HD serum sodium level < 125 mEq / L and post-HD serum sodium levels that increased by ≥ 12 mEq / L from their pre-dialysis level, were studied.
Serum sodium was analyzed before and within 24 h after a HD session.
HD was performed using bicarbonate solution, with the sodium concentration being 140 meq / L.
The duration of the dialysis session was based on the discretion of the treating nephrologist.
Patients were examined for any neurological symptoms or signs before and after HD and for up to two weeks.
Magnetic resonance imaging was performed in required cases.
None of the 52 patients with azotemia, despite inadvertent rapid correction of hyponatremia with HD, developed ODS.
This study suggests that patients with azotemia do not develop ODS on rapid correction of hyponatremia by HD, which suggests a possible protective role of azotemia on the brain from osmotic demyelination.
However, the mechanism by which azotemia protects the brain from demyelination in humans is largely hypothetical and further studies are needed to answer this question.
American Psychological Association (APA)
Dhrolia, Murtada F.& Akhtar, Sayyid F.& Ahmad, Ijaz& Naqvi, Anwar& Rizvi, Adib. 2014. Azotemia protects the brain from osmotic demyelination on rapid correction of hyponatremia. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 3, pp.558-566.
https://search.emarefa.net/detail/BIM-370907
Modern Language Association (MLA)
Dhrolia, Murtada F.…[et al.]. Azotemia protects the brain from osmotic demyelination on rapid correction of hyponatremia. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 3 (2014), pp.558-566.
https://search.emarefa.net/detail/BIM-370907
American Medical Association (AMA)
Dhrolia, Murtada F.& Akhtar, Sayyid F.& Ahmad, Ijaz& Naqvi, Anwar& Rizvi, Adib. Azotemia protects the brain from osmotic demyelination on rapid correction of hyponatremia. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 3, pp.558-566.
https://search.emarefa.net/detail/BIM-370907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 565-566
Record ID
BIM-370907