Influence of ultraviolet light on pathogenic determinant SAP2 gene of Candida albicans strain (SC5314)‎

الملخص EN

Extracellular proteolytic activity play a great role in Candida albicans pathogenicity and is produced by a family of 10 secreted aspartyl proteinase (sap) genes.

Sap2 is the most important member of them.

The present work was done to study the influence of ultraviolet on sap2 gene.

Isolation of genomic DNA for PCR analysis and sequencing to detect sap2 gene in radiated and non radiated Candida albicans were done.

The results reveal that, sap2 gene sequencing was changed after UV.

The change in some location of the gene lead to decreasing its ability to secrete Aspartyl proteinase.