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Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginineserin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy
المؤلفون المشاركون
Abd al-Ghani, Amal
al-Wahib, Salah
Husayn, Nasir
al-Wahib, Maysa
al-Yatama, Nur
Dashti, Ali Abd al-Samad
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 25، العدد 3 (30 يونيو/حزيران 2014)، ص ص. 577-581، 5ص.
الناشر
تاريخ النشر
2014-06-30
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
- الأحماض الأمينية
- النوكليوتيدات
- اعتلال الكلى السكري
- الاضطرابات الوراثية
- تعدد الأشكال الوراثية
- ورم البلازما
- التشخيص
- الإريثروبويتين
- سوبر أكسيد ديسميوتاز
الملخص EN
A number of genes have been identified in diabetic nephropathy.
Association between diabetes-associated nephropathy and polymorphisms in the erythropoietin (EPO) gene, variants in the superoxide dismutase 1 (SOD1) gene and plasmacytoma variant translocation 1 (PVT1) gene have been identified.
The EPO, SOD1:SFRS15 and PVT1 genes were genotyped using the single nucleotide polymorphism (SNP) technique in 38 diabetic nephropathy patients (Group 1) compared with 64 diabetic type 2 subjects without nephropathy (Group 2) at the Mubarak Alkabeer Hospital, Kuwait.
The frequency of the risk allele T of the EPO (rs1617640) gene was high in both groups (0.96 in Group 1 and 0.92 in Group 2).
Similarly, SNPs of the PVT1 (rs2720709) gene showed a higher frequency of the risk allele G in both groups (0.70 in the Group 1 and 0.68 in Group 2).
Although the frequency of the risk allele A was higher than the frequency of the non-risk allele C of the SOD1 : SFRS15 gene in both groups, the lowest probability value was observed in those gene SNPs (P = 0.05).
We observed that the A allele of the SOD1 : SFRS15 gene (rs17880135) was more frequently present in Group 1 (0.75) compared with Group 2 (0.62).
Susceptibility to diabetes-associated nephropathy is partially mediated by genetic predisposition, and screening tests may open the gate for new therapeutic approaches.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Wahib, Maysa& al-Wahib, Salah& al-Yatama, Nur& Dashti, Ali Abd al-Samad& Abd al-Ghani, Amal& Husayn, Nasir. 2014. Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginineserin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 3, pp.577-581.
https://search.emarefa.net/detail/BIM-371152
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Wahib, Maysa…[et al.]. Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginineserin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 3 (2014), pp.577-581.
https://search.emarefa.net/detail/BIM-371152
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Wahib, Maysa& al-Wahib, Salah& al-Yatama, Nur& Dashti, Ali Abd al-Samad& Abd al-Ghani, Amal& Husayn, Nasir. Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginineserin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 3, pp.577-581.
https://search.emarefa.net/detail/BIM-371152
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 580-581
رقم السجل
BIM-371152
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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