Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginineserin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy
Joint Authors
Abd al-Ghani, Amal
al-Wahib, Salah
Husayn, Nasir
al-Wahib, Maysa
al-Yatama, Nur
Dashti, Ali Abd al-Samad
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 25, Issue 3 (30 Jun. 2014), pp.577-581, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2014-06-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
- Amino acids
- Nucleotides
- Diabetic nephropathies
- Genetic disorders
- Genetic polymorphisms
- Plasmacytoma
- Diagnosis
- Erythropoietin
- Superoxide dismutase
Abstract EN
A number of genes have been identified in diabetic nephropathy.
Association between diabetes-associated nephropathy and polymorphisms in the erythropoietin (EPO) gene, variants in the superoxide dismutase 1 (SOD1) gene and plasmacytoma variant translocation 1 (PVT1) gene have been identified.
The EPO, SOD1:SFRS15 and PVT1 genes were genotyped using the single nucleotide polymorphism (SNP) technique in 38 diabetic nephropathy patients (Group 1) compared with 64 diabetic type 2 subjects without nephropathy (Group 2) at the Mubarak Alkabeer Hospital, Kuwait.
The frequency of the risk allele T of the EPO (rs1617640) gene was high in both groups (0.96 in Group 1 and 0.92 in Group 2).
Similarly, SNPs of the PVT1 (rs2720709) gene showed a higher frequency of the risk allele G in both groups (0.70 in the Group 1 and 0.68 in Group 2).
Although the frequency of the risk allele A was higher than the frequency of the non-risk allele C of the SOD1 : SFRS15 gene in both groups, the lowest probability value was observed in those gene SNPs (P = 0.05).
We observed that the A allele of the SOD1 : SFRS15 gene (rs17880135) was more frequently present in Group 1 (0.75) compared with Group 2 (0.62).
Susceptibility to diabetes-associated nephropathy is partially mediated by genetic predisposition, and screening tests may open the gate for new therapeutic approaches.
American Psychological Association (APA)
al-Wahib, Maysa& al-Wahib, Salah& al-Yatama, Nur& Dashti, Ali Abd al-Samad& Abd al-Ghani, Amal& Husayn, Nasir. 2014. Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginineserin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation،Vol. 25, no. 3, pp.577-581.
https://search.emarefa.net/detail/BIM-371152
Modern Language Association (MLA)
al-Wahib, Maysa…[et al.]. Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginineserin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation Vol. 25, no. 3 (2014), pp.577-581.
https://search.emarefa.net/detail/BIM-371152
American Medical Association (AMA)
al-Wahib, Maysa& al-Wahib, Salah& al-Yatama, Nur& Dashti, Ali Abd al-Samad& Abd al-Ghani, Amal& Husayn, Nasir. Single nucleotide polymorphisms at erythropoietin, superoxide dismutase 1, splicing factor, arginineserin-rich 15 and plasmacytoma variant translocation genes association with diabetic nephropathy. Saudi Journal of Kidney Diseases and Transplantation. 2014. Vol. 25, no. 3, pp.577-581.
https://search.emarefa.net/detail/BIM-371152
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 580-581
Record ID
BIM-371152