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Efficacy of folate and vitamin B12 in lowering Homocysteine concentration in hemodialysis patients
المؤلفون المشاركون
Azadi Bakhsh, Nassim
Husayni, Rahebeh Shakir
Atabak, Shahnaz
Nateghiyan, Navid
Golestan, Banafsheh
Rad, Anahita Hooshyar
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 20، العدد 5 (31 أكتوبر/تشرين الأول 2009)، ص ص. 779-788، 10ص.
الناشر
تاريخ النشر
2009-10-31
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
To evaluate the efficacy of supplementation with high dose folic acid with and without vitamin B 12 in lowering plasma total homocysteine (tHcy) concentrations in hemodialysis (HD) patients, we studied 36 HD patients randomized into four groups according to the received therapeutic regimen: group I (only folic acid (FA), 5 mg/day), group II (FA, 5 mg/day + vitamin B 12 , 1 mg/day) group III (only FA, 15 mg/day), group IV (FA, 15 mg/day, vitamin B 12 , 1 mg/day) for a period of 8 weeks.
Plasma tHcy and serum FA and vitamin B 12 levels were measured at baseline and after the supplementation period.
Dietary intakes were assessed during the study period.
At baseline, 27.8% of the patients had normal levels of tHcy and 72.2% had hyperhomocysteinemia.
After supplementation, plasma tHcy increased by 1.35% in group I and decreased by 6.99%, 14.54% and 30.09% in groups II, III and IV respectively, which was only significant in group IV (P= 0.014).
The patients did not show any significant changes in serum folic acid, but a significant change in serum vitamin B 12 in group IV (P= 0.006).
Percentage of patients reaching normal levels of plasma tHcy was 5.6 fold higher in group IV than in the reference group (group I).
No correlations were found between changes of plasma tHcy levels and dietary intakes.
We conclude that oral supplementation with 15 mg/day folic acid together with 1 mg/day of vitamin B 12 is effective in reducing tHcy levels in HD patients.
These supplements also have a desirable effect on serum folic acid and vitamin B12.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Azadi Bakhsh, Nassim& Husayni, Rahebeh Shakir& Atabak, Shahnaz& Nateghiyan, Navid& Golestan, Banafsheh& Rad, Anahita Hooshyar. 2009. Efficacy of folate and vitamin B12 in lowering Homocysteine concentration in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 5, pp.779-788.
https://search.emarefa.net/detail/BIM-37385
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Azadi Bakhsh, Nassim…[et al.]. Efficacy of folate and vitamin B12 in lowering Homocysteine concentration in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 5 (Oct. 2009), pp.779-788.
https://search.emarefa.net/detail/BIM-37385
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Azadi Bakhsh, Nassim& Husayni, Rahebeh Shakir& Atabak, Shahnaz& Nateghiyan, Navid& Golestan, Banafsheh& Rad, Anahita Hooshyar. Efficacy of folate and vitamin B12 in lowering Homocysteine concentration in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 5, pp.779-788.
https://search.emarefa.net/detail/BIM-37385
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 786-788.
رقم السجل
BIM-37385
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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