Efficacy of folate and vitamin B12 in lowering Homocysteine concentration in hemodialysis patients
Joint Authors
Azadi Bakhsh, Nassim
Husayni, Rahebeh Shakir
Atabak, Shahnaz
Nateghiyan, Navid
Golestan, Banafsheh
Rad, Anahita Hooshyar
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 20, Issue 5 (31 Oct. 2009), pp.779-788, 10 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2009-10-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
To evaluate the efficacy of supplementation with high dose folic acid with and without vitamin B 12 in lowering plasma total homocysteine (tHcy) concentrations in hemodialysis (HD) patients, we studied 36 HD patients randomized into four groups according to the received therapeutic regimen: group I (only folic acid (FA), 5 mg/day), group II (FA, 5 mg/day + vitamin B 12 , 1 mg/day) group III (only FA, 15 mg/day), group IV (FA, 15 mg/day, vitamin B 12 , 1 mg/day) for a period of 8 weeks.
Plasma tHcy and serum FA and vitamin B 12 levels were measured at baseline and after the supplementation period.
Dietary intakes were assessed during the study period.
At baseline, 27.8% of the patients had normal levels of tHcy and 72.2% had hyperhomocysteinemia.
After supplementation, plasma tHcy increased by 1.35% in group I and decreased by 6.99%, 14.54% and 30.09% in groups II, III and IV respectively, which was only significant in group IV (P= 0.014).
The patients did not show any significant changes in serum folic acid, but a significant change in serum vitamin B 12 in group IV (P= 0.006).
Percentage of patients reaching normal levels of plasma tHcy was 5.6 fold higher in group IV than in the reference group (group I).
No correlations were found between changes of plasma tHcy levels and dietary intakes.
We conclude that oral supplementation with 15 mg/day folic acid together with 1 mg/day of vitamin B 12 is effective in reducing tHcy levels in HD patients.
These supplements also have a desirable effect on serum folic acid and vitamin B12.
American Psychological Association (APA)
Azadi Bakhsh, Nassim& Husayni, Rahebeh Shakir& Atabak, Shahnaz& Nateghiyan, Navid& Golestan, Banafsheh& Rad, Anahita Hooshyar. 2009. Efficacy of folate and vitamin B12 in lowering Homocysteine concentration in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 5, pp.779-788.
https://search.emarefa.net/detail/BIM-37385
Modern Language Association (MLA)
Azadi Bakhsh, Nassim…[et al.]. Efficacy of folate and vitamin B12 in lowering Homocysteine concentration in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 5 (Oct. 2009), pp.779-788.
https://search.emarefa.net/detail/BIM-37385
American Medical Association (AMA)
Azadi Bakhsh, Nassim& Husayni, Rahebeh Shakir& Atabak, Shahnaz& Nateghiyan, Navid& Golestan, Banafsheh& Rad, Anahita Hooshyar. Efficacy of folate and vitamin B12 in lowering Homocysteine concentration in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 5, pp.779-788.
https://search.emarefa.net/detail/BIM-37385
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 786-788.
Record ID
BIM-37385