Prevalence of thrombophilic gene polymorphisms (FVL G1691A and MTHFR C677T) in patients with myocardial infarction
المؤلفون المشاركون
Izzat, Hamdiyah
Atiyyah, Fatimah A.
Mukhtar, Amal
al-Tukhi, Hanan M.
al-Khuli, Nashwa Y.
al-Alfi, Muhammad Noshy
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 15، العدد 2 (30 إبريل/نيسان 2014)، ص ص. 113-123، 11ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2014-04-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Inherited thrombophilia may be caused by mutations, polymorphisms in a variety of genes mainly involved in haemostatic pathways.
Aim of the study, was to find the prevalence of thrombophilic gene factor V Leiden (FVL) and methylene tetrahydrofolate reductase (MTHFR) gene polymorphism in patients with myocardial infarction (MI), aiming at early diagnostic methods and guiding preventive procedures.
Subjects and methods : This study was carried on 30 patients who survived their first MI as compared to 15 healthy volunteers.
Patients and controls were subjected to history, physical examination.
Factor VL G1691A and MTHFR C677T genotypes were determined by RT PCR.
Results : The prevalence of heterozygous FVL GA genotype was significantly higher among MI patients as compared to the control group.
The prevalence of mutant homozygous AA was significantly higher in MI patients as compared to control.
The low risk cases had a higher frequency of GA genotype as compared to high risk cases.
As regards MTHFR C677T gene polymorphism, the prevalence of heterozygous MTHFR C677T CT genotype showed significant increase in MI patients compared with the control group.
The prevalence of mutant homozygous TT genotype was significantly higher in MI patients as compared to the control group.
The low risk cases had a higher frequency of heterozygous MTHFR C677T CT genotype than high risk cases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Izzat, Hamdiyah& Atiyyah, Fatimah A.& Mukhtar, Amal& al-Tukhi, Hanan M.& al-Alfi, Muhammad Noshy& al-Khuli, Nashwa Y.. 2014. Prevalence of thrombophilic gene polymorphisms (FVL G1691A and MTHFR C677T) in patients with myocardial infarction. The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 2, pp.113-123.
https://search.emarefa.net/detail/BIM-374450
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Alfi, Muhammad Noshy…[et al.]. Prevalence of thrombophilic gene polymorphisms (FVL G1691A and MTHFR C677T) in patients with myocardial infarction. The Egyptian Journal of Medical Human Genetics Vol. 15, no. 2 (Apr. 2014), pp.113-123.
https://search.emarefa.net/detail/BIM-374450
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Izzat, Hamdiyah& Atiyyah, Fatimah A.& Mukhtar, Amal& al-Tukhi, Hanan M.& al-Alfi, Muhammad Noshy& al-Khuli, Nashwa Y.. Prevalence of thrombophilic gene polymorphisms (FVL G1691A and MTHFR C677T) in patients with myocardial infarction. The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 2, pp.113-123.
https://search.emarefa.net/detail/BIM-374450
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 121-123
رقم السجل
BIM-374450
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر