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Prevalence of thrombophilic gene polymorphisms (FVL G1691A and MTHFR C677T) in patients with myocardial infarction
Joint Authors
Izzat, Hamdiyah
Atiyyah, Fatimah A.
Mukhtar, Amal
al-Tukhi, Hanan M.
al-Khuli, Nashwa Y.
al-Alfi, Muhammad Noshy
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 15, Issue 2 (30 Apr. 2014), pp.113-123, 11 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Topics
Abstract EN
Background : Inherited thrombophilia may be caused by mutations, polymorphisms in a variety of genes mainly involved in haemostatic pathways.
Aim of the study, was to find the prevalence of thrombophilic gene factor V Leiden (FVL) and methylene tetrahydrofolate reductase (MTHFR) gene polymorphism in patients with myocardial infarction (MI), aiming at early diagnostic methods and guiding preventive procedures.
Subjects and methods : This study was carried on 30 patients who survived their first MI as compared to 15 healthy volunteers.
Patients and controls were subjected to history, physical examination.
Factor VL G1691A and MTHFR C677T genotypes were determined by RT PCR.
Results : The prevalence of heterozygous FVL GA genotype was significantly higher among MI patients as compared to the control group.
The prevalence of mutant homozygous AA was significantly higher in MI patients as compared to control.
The low risk cases had a higher frequency of GA genotype as compared to high risk cases.
As regards MTHFR C677T gene polymorphism, the prevalence of heterozygous MTHFR C677T CT genotype showed significant increase in MI patients compared with the control group.
The prevalence of mutant homozygous TT genotype was significantly higher in MI patients as compared to the control group.
The low risk cases had a higher frequency of heterozygous MTHFR C677T CT genotype than high risk cases.
American Psychological Association (APA)
Izzat, Hamdiyah& Atiyyah, Fatimah A.& Mukhtar, Amal& al-Tukhi, Hanan M.& al-Alfi, Muhammad Noshy& al-Khuli, Nashwa Y.. 2014. Prevalence of thrombophilic gene polymorphisms (FVL G1691A and MTHFR C677T) in patients with myocardial infarction. The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 2, pp.113-123.
https://search.emarefa.net/detail/BIM-374450
Modern Language Association (MLA)
al-Alfi, Muhammad Noshy…[et al.]. Prevalence of thrombophilic gene polymorphisms (FVL G1691A and MTHFR C677T) in patients with myocardial infarction. The Egyptian Journal of Medical Human Genetics Vol. 15, no. 2 (Apr. 2014), pp.113-123.
https://search.emarefa.net/detail/BIM-374450
American Medical Association (AMA)
Izzat, Hamdiyah& Atiyyah, Fatimah A.& Mukhtar, Amal& al-Tukhi, Hanan M.& al-Alfi, Muhammad Noshy& al-Khuli, Nashwa Y.. Prevalence of thrombophilic gene polymorphisms (FVL G1691A and MTHFR C677T) in patients with myocardial infarction. The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 2, pp.113-123.
https://search.emarefa.net/detail/BIM-374450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 121-123
Record ID
BIM-374450