Glucose metabolism abnormalities among pediatric acute lymphoblastic leukemia survivors : assessment and relation to body mass index and waist to hip ratio

الملخص EN

-Background: As survival rates of pediatric acute lymphoblastic leukemia (ALL) improve, attention is turning to side and late effects of therapy including glucose metabolism abnormalities.

Objective: To asses the presence of abnormal glucose metabolism in pediatric ALL survivors and its possible relation to body mass index (BMI), waist to hip ratio and treatment related factors.

Subjects and methods: Retrospective study with a prospective follow-up of 12 ALL survivors who had been off chemotherapy for >9 months was done.

Fifteen healthy sex and age matched children were involved as controls.

Body mass index (BMI) waist to hip ratio (WHR), and Oral glucose tolerance test (OGTT) were performed with assessment of glycated hemoglobin (Hb A1C) and insulin sensitivity indices.

Results: At study time the mean BMI, WHR, all components of the OGTT (except the 2 h post load glucose), all indices of insulin sensitivity and the mean Hb A1C% were significantly higher compared to those of the controls.

Two survivors (16.6%) developed transient hyperglycemia