Effect of nasal continuous positive airway pressure on inflammatory mediators in patients with overlap syndrome
المؤلفون المشاركون
Fathi, Ahmad
Arif, Hasan
Mansur, Hisham A. K. A.
المصدر
Egyptian Journal of Ear, Nose, Throat and Allied Sciences
العدد
المجلد 12، العدد 2 (31 يوليو/تموز 2011)، ص ص. 99-104، 6ص.
الناشر
الجمعية المصرية للأذن و الأنف و الحنجرة و العلوم المشتركة
تاريخ النشر
2011-07-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Overlap syndrome is the coexistence of obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD).
Both OSAS and COPD are associated with an increase in a variety of systemic inflammatory markers such as tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), and C-reactive protein (CRP).
Nasal continuous positive airway pressure (CPAP) has been shown to improve overnight oxygenation in patients with overlap syndrome.
It stands to reason that effective therapy for the sleep disorder would favorably affect the inflammatory cascade.
Methods: Thirty-five patients with overlap syndrome were selected for the study.
Tumor necrosis factor-alpha, interleukin-6, and C-reactive protein were measured in patients with overlap syndrome before and after treatment with CPAP.
Results: Forced expiratory volume in 1st second (FEV1%) was 55.3 ± 4.58 before and 57.1 ± 4.78 after CPAP treatment (P 0.13).
Forced vital capacity (FVC%) was 88.5 ± 3.26 before and 88.6 ± 3.13 after CPAP (P 0.97).
FEV1/FVC% was 62.2 ±4.14 before and 64.3 ± 4.24 after CPAP (P 0.064) IL-6 was 3.13 ± 0.56 before and 1.87 ±0.15 after CPAP (P <0.0001).
TNF-a was 7.4± 1.29 before and 4.77 ± 0.96 after CPAP (P < 0.0001).
CRP was 0.83 ± 0.1 before and 0.44 ±0.18 after CPAP (P < 0.0001).
Conclusion: There is statistically significant difference in inflammatory markers levels before and after CPAP treatment in patients with overlap syndrome.
This suggests that inflammation in overlap syndrome may be mediated by inflammatory markers in the form of CRP, IL-6, and TNF-a.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mansur, Hisham A. K. A.& Fathi, Ahmad& Arif, Hasan. 2011. Effect of nasal continuous positive airway pressure on inflammatory mediators in patients with overlap syndrome. Egyptian Journal of Ear, Nose, Throat and Allied Sciences،Vol. 12, no. 2, pp.99-104.
https://search.emarefa.net/detail/BIM-374951
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mansur, Hisham A. K. A.…[et al.]. Effect of nasal continuous positive airway pressure on inflammatory mediators in patients with overlap syndrome. Egyptian Journal of Ear, Nose, Throat and Allied Sciences Vol. 12, no. 2 (Jul. 2011), pp.99-104.
https://search.emarefa.net/detail/BIM-374951
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mansur, Hisham A. K. A.& Fathi, Ahmad& Arif, Hasan. Effect of nasal continuous positive airway pressure on inflammatory mediators in patients with overlap syndrome. Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 2011. Vol. 12, no. 2, pp.99-104.
https://search.emarefa.net/detail/BIM-374951
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 103-104
رقم السجل
BIM-374951
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر