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Effect of nasal continuous positive airway pressure on inflammatory mediators in patients with overlap syndrome
Joint Authors
Fathi, Ahmad
Arif, Hasan
Mansur, Hisham A. K. A.
Source
Egyptian Journal of Ear, Nose, Throat and Allied Sciences
Issue
Vol. 12, Issue 2 (31 Jul. 2011), pp.99-104, 6 p.
Publisher
Egyptian Society of Ear Nose Throat and Allied Science
Publication Date
2011-07-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background: Overlap syndrome is the coexistence of obstructive sleep apnea syndrome (OSAS) and chronic obstructive pulmonary disease (COPD).
Both OSAS and COPD are associated with an increase in a variety of systemic inflammatory markers such as tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), and C-reactive protein (CRP).
Nasal continuous positive airway pressure (CPAP) has been shown to improve overnight oxygenation in patients with overlap syndrome.
It stands to reason that effective therapy for the sleep disorder would favorably affect the inflammatory cascade.
Methods: Thirty-five patients with overlap syndrome were selected for the study.
Tumor necrosis factor-alpha, interleukin-6, and C-reactive protein were measured in patients with overlap syndrome before and after treatment with CPAP.
Results: Forced expiratory volume in 1st second (FEV1%) was 55.3 ± 4.58 before and 57.1 ± 4.78 after CPAP treatment (P 0.13).
Forced vital capacity (FVC%) was 88.5 ± 3.26 before and 88.6 ± 3.13 after CPAP (P 0.97).
FEV1/FVC% was 62.2 ±4.14 before and 64.3 ± 4.24 after CPAP (P 0.064) IL-6 was 3.13 ± 0.56 before and 1.87 ±0.15 after CPAP (P <0.0001).
TNF-a was 7.4± 1.29 before and 4.77 ± 0.96 after CPAP (P < 0.0001).
CRP was 0.83 ± 0.1 before and 0.44 ±0.18 after CPAP (P < 0.0001).
Conclusion: There is statistically significant difference in inflammatory markers levels before and after CPAP treatment in patients with overlap syndrome.
This suggests that inflammation in overlap syndrome may be mediated by inflammatory markers in the form of CRP, IL-6, and TNF-a.
American Psychological Association (APA)
Mansur, Hisham A. K. A.& Fathi, Ahmad& Arif, Hasan. 2011. Effect of nasal continuous positive airway pressure on inflammatory mediators in patients with overlap syndrome. Egyptian Journal of Ear, Nose, Throat and Allied Sciences،Vol. 12, no. 2, pp.99-104.
https://search.emarefa.net/detail/BIM-374951
Modern Language Association (MLA)
Mansur, Hisham A. K. A.…[et al.]. Effect of nasal continuous positive airway pressure on inflammatory mediators in patients with overlap syndrome. Egyptian Journal of Ear, Nose, Throat and Allied Sciences Vol. 12, no. 2 (Jul. 2011), pp.99-104.
https://search.emarefa.net/detail/BIM-374951
American Medical Association (AMA)
Mansur, Hisham A. K. A.& Fathi, Ahmad& Arif, Hasan. Effect of nasal continuous positive airway pressure on inflammatory mediators in patients with overlap syndrome. Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 2011. Vol. 12, no. 2, pp.99-104.
https://search.emarefa.net/detail/BIM-374951
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 103-104
Record ID
BIM-374951