Circulating MCP-1 level and ~2518 gene polymorphism as a marker of nephropathy development in Egyptian patients
المؤلفون المشاركون
Muhammad, Walid S.
Hasan, Azzah M.
Naji, Halah
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 11، العدد 2 (31 ديسمبر/كانون الأول 2010)، ص ص. 159-166، 8ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2010-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Abstract Objective : Monocyte chemoattractant protein-1 (MCP-1) is a member of CC chemokine that plays an important role in the recruitment of monocytes/macrophages into renal tubulointerstitium.
A biallelic A/G polymorphism at position -2518 in the MCP-1 gene was found to regulate MCP-1 expression.
MCP-1 and its A/G gene polymorphism have been implicated in the pathogenesis of some renal diseases.
The aim of this study was to evaluate the role of circulating MCP-1 level and the relevance of functional genetic variations of MCP-1 as early predictors of the development of glomerulonephropathy (GN) in Egyptian patients.
Methods : This is a case control study that was conducted in 50 GN patients, 20 non-GN cases and 20 ethnically matched healthy controls.
MCP-1 serum level was detected by ELISA technique, while genotyping of polymorphisms in the MCP-1 genes was performed using a polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) detection.
Results : High MCP-1 circulating levels and subsequently MCP-1 _2518G polymorphism are associated with the developing of nephropathy irrespective to the underlying etiology.
MCP-1 serum level was significantly high when compared with healthy controls (P = 0.0007) and non-GN cases (P = 0.01).
There was predominance of A allele at _2518 of MCP-1 gene in healthy controls (87.5 %) and non-GN cases (77.5 %).
The frequency of the _2518G MCP-1 polymorphism was significantly higher in GN patients than in healthy controls (P < 0.0001 ; OR = 15.6) and non-GN cases (P < 0.0001 ; OR = 7.7).
Interestingly, homozygosity for G allele plays the main role in such association.
Conclusion : A / G polymorphism in MCP-1 gene and subsequently high circulating MCP-1 level confer a relevant role in the susceptibility to the development of nephropathy in the Egyptian population denoting that MCP-1 system could be an early predictor of such renal complication.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hasan, Azzah M.& Naji, Halah& Muhammad, Walid S.. 2010. Circulating MCP-1 level and ~2518 gene polymorphism as a marker of nephropathy development in Egyptian patients. The Egyptian Journal of Medical Human Genetics،Vol. 11, no. 2, pp.159-166.
https://search.emarefa.net/detail/BIM-380071
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Naji, Halah…[et al.]. Circulating MCP-1 level and ~2518 gene polymorphism as a marker of nephropathy development in Egyptian patients. The Egyptian Journal of Medical Human Genetics Vol. 11, no. 2 (2010), pp.159-166.
https://search.emarefa.net/detail/BIM-380071
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hasan, Azzah M.& Naji, Halah& Muhammad, Walid S.. Circulating MCP-1 level and ~2518 gene polymorphism as a marker of nephropathy development in Egyptian patients. The Egyptian Journal of Medical Human Genetics. 2010. Vol. 11, no. 2, pp.159-166.
https://search.emarefa.net/detail/BIM-380071
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 165-166
رقم السجل
BIM-380071
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر