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Potential impact of silymarin in combination with chlorogenic acid andor melatonin in combating cardiomyopathy induced by carbon tetrachloride
المؤلفون المشاركون
al-Rashid, Nouf M.
al-Rashid, Nawal M.
Faddah, L. M.
Muhammad, Azzah M.
Muhammad, Raisa A.
al-Amin, Maha
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 21، العدد 3 (31 يوليو/تموز 2014)، ص ص. 265-274، 10ص.
الناشر
تاريخ النشر
2014-07-31
دولة النشر
السعودية
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
The aimof this study was to investigate the effective role of silymarin either alone or in combinationwith chlorogenic acid and / ormelatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction.
CCl4 (l.2 ml / kg body weight) was administered as a single dose intraperitoneally.
The results revealed that the administration of silymarin alone or in combinationwith chlorogenic acid (CGA) and / or melatonin for 21 consecutive days, 24 h after CCl4 injection to rats, markedly ameliorated the increases in serum markers of cardiac infarction, including troponin T and creatine kinase-MB (CK-MB), as well as increases in the pro-inflammatory biomarkers, including interleukin- 6 (IL-6), interferon-c (IFN-c) in serum and tumor necrosis factor-a (TNF-a) and C-reactive protein in cardiac tissue compared to CCl4 intoxicated rats.
The used agents also successfully modulated the alteration in vascular endothelial growth factor (VEGF) in serum and the oxidative DNA damage and the increase in the apoptosis marker caspase 3 in cardiac tissue in response to CCl4 toxicity.
The present biochemical results are supported by histo-pathological examination.The current results proved that treatment with silymarin in combination with CGA and melatonin was the most effective one in ameliorating the toxicity of CCl4 induced cardiac damage and this may support the use of this combination as an effective drug to treat cardiac damage induced by toxic agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Rashid, Nouf M.& al-Rashid, Nawal M.& Faddah, L. M.& Muhammad, Azzah M.& Muhammad, Raisa A.& al-Amin, Maha. 2014. Potential impact of silymarin in combination with chlorogenic acid andor melatonin in combating cardiomyopathy induced by carbon tetrachloride. Saudi Journal of Biological Sciences،Vol. 21, no. 3, pp.265-274.
https://search.emarefa.net/detail/BIM-380176
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Rashid, Nawal M.…[et al.]. Potential impact of silymarin in combination with chlorogenic acid andor melatonin in combating cardiomyopathy induced by carbon tetrachloride. Saudi Journal of Biological Sciences Vol. 21, no. 3 (2014), pp.265-274.
https://search.emarefa.net/detail/BIM-380176
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Rashid, Nouf M.& al-Rashid, Nawal M.& Faddah, L. M.& Muhammad, Azzah M.& Muhammad, Raisa A.& al-Amin, Maha. Potential impact of silymarin in combination with chlorogenic acid andor melatonin in combating cardiomyopathy induced by carbon tetrachloride. Saudi Journal of Biological Sciences. 2014. Vol. 21, no. 3, pp.265-274.
https://search.emarefa.net/detail/BIM-380176
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 272-274
رقم السجل
BIM-380176
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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