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Potential impact of silymarin in combination with chlorogenic acid andor melatonin in combating cardiomyopathy induced by carbon tetrachloride
Joint Authors
al-Rashid, Nouf M.
al-Rashid, Nawal M.
Faddah, L. M.
Muhammad, Azzah M.
Muhammad, Raisa A.
al-Amin, Maha
Source
Saudi Journal of Biological Sciences
Issue
Vol. 21, Issue 3 (31 Jul. 2014), pp.265-274, 10 p.
Publisher
Publication Date
2014-07-31
Country of Publication
Saudi Arabia
No. of Pages
10
Main Subjects
Topics
Abstract EN
The aimof this study was to investigate the effective role of silymarin either alone or in combinationwith chlorogenic acid and / ormelatonin against the toxic impact of carbon tetrachloride (CCl4) induced cardiac infarction.
CCl4 (l.2 ml / kg body weight) was administered as a single dose intraperitoneally.
The results revealed that the administration of silymarin alone or in combinationwith chlorogenic acid (CGA) and / or melatonin for 21 consecutive days, 24 h after CCl4 injection to rats, markedly ameliorated the increases in serum markers of cardiac infarction, including troponin T and creatine kinase-MB (CK-MB), as well as increases in the pro-inflammatory biomarkers, including interleukin- 6 (IL-6), interferon-c (IFN-c) in serum and tumor necrosis factor-a (TNF-a) and C-reactive protein in cardiac tissue compared to CCl4 intoxicated rats.
The used agents also successfully modulated the alteration in vascular endothelial growth factor (VEGF) in serum and the oxidative DNA damage and the increase in the apoptosis marker caspase 3 in cardiac tissue in response to CCl4 toxicity.
The present biochemical results are supported by histo-pathological examination.The current results proved that treatment with silymarin in combination with CGA and melatonin was the most effective one in ameliorating the toxicity of CCl4 induced cardiac damage and this may support the use of this combination as an effective drug to treat cardiac damage induced by toxic agents.
American Psychological Association (APA)
al-Rashid, Nouf M.& al-Rashid, Nawal M.& Faddah, L. M.& Muhammad, Azzah M.& Muhammad, Raisa A.& al-Amin, Maha. 2014. Potential impact of silymarin in combination with chlorogenic acid andor melatonin in combating cardiomyopathy induced by carbon tetrachloride. Saudi Journal of Biological Sciences،Vol. 21, no. 3, pp.265-274.
https://search.emarefa.net/detail/BIM-380176
Modern Language Association (MLA)
al-Rashid, Nawal M.…[et al.]. Potential impact of silymarin in combination with chlorogenic acid andor melatonin in combating cardiomyopathy induced by carbon tetrachloride. Saudi Journal of Biological Sciences Vol. 21, no. 3 (2014), pp.265-274.
https://search.emarefa.net/detail/BIM-380176
American Medical Association (AMA)
al-Rashid, Nouf M.& al-Rashid, Nawal M.& Faddah, L. M.& Muhammad, Azzah M.& Muhammad, Raisa A.& al-Amin, Maha. Potential impact of silymarin in combination with chlorogenic acid andor melatonin in combating cardiomyopathy induced by carbon tetrachloride. Saudi Journal of Biological Sciences. 2014. Vol. 21, no. 3, pp.265-274.
https://search.emarefa.net/detail/BIM-380176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 272-274
Record ID
BIM-380176