A descriptive study of plasma cell dyscrasias in Egyptian population

المؤلفون المشاركون

Qasim, Hibah A.
Qasim, Nimat M.
al-Zawam, Hamdi
al-Husayni, Nuha M.
Abd al-Azim, Hamdi
al-Nahhas, Tamir

المصدر

Journal of the Egyptian National Cancer Institute

العدد

المجلد 26، العدد 2 (30 يونيو/حزيران 2014)، ص ص. 67-71، 5ص.

الناشر

جامعة القاهرة المعهد القومي للأورام

تاريخ النشر

2014-06-30

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الطب البشري

الموضوعات

الملخص EN

Background : Plasma cell dyscrasias (PCDs) refer to a spectrum of disorders characterized by the monoclonal proliferation of lymphoplasmacytic cells in the bone marrow and, sometimes, tissue deposition of monoclonal immunoglobulins or their components.

These disorders include multiple myeloma (MM) and Waldenstro¨ m’s macroglobulinemia, as well as rare conditions such as light-chain deposition disease (LCDD) and heavy-chain diseases (HCDs).

The worldwide annual incidence of MM is estimated at 86,000, which is approximately 0.8 % of all new cancer cases.

Purpose : Our retrospective study aims to highlight the immunologic and epidemiological features of PCDs mainly MM in Egyptian patients and compare our results with those of other populations.

Methods : Two hundred seventeen Egyptian patients with PCD were enrolled in the study.

Serum, urine protein electrophoresis and immunofixation were used to demonstrate M protein.

Results: One hundred thirty-eight patients (63.6 %) had IgG monoclonal band, 38 patients (17.5 %) had IgA, 12 patients (5.5 %) had Waldenstro¨ m’s macroglobulinemia (IgM monoclonal band) and 29 patients (13.4 %) were light chain myeloma.

One hundred fifty-one (70 %) were Kappa chain positive and 66 patients (30 %) were lumbda positive.

Conventional cytogenetics was available for 40 patients ; of them12 patients (30 %) showed 13q-.

Mean OS was 37.5 months (1–84 months).

Survival analysis was statistically insignificant according to age, sex and ISS or type of treatment (P value > 0.05).

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Qasim, Nimat M.& al-Zawam, Hamdi& Qasim, Hibah A.& al-Nahhas, Tamir& al-Husayni, Nuha M.& Abd al-Azim, Hamdi. 2014. A descriptive study of plasma cell dyscrasias in Egyptian population. Journal of the Egyptian National Cancer Institute،Vol. 26, no. 2, pp.67-71.
https://search.emarefa.net/detail/BIM-380283

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Qasim, Nimat M.…[et al.]. A descriptive study of plasma cell dyscrasias in Egyptian population. Journal of the Egyptian National Cancer Institute Vol. 26, no. 2 (2014), pp.67-71.
https://search.emarefa.net/detail/BIM-380283

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Qasim, Nimat M.& al-Zawam, Hamdi& Qasim, Hibah A.& al-Nahhas, Tamir& al-Husayni, Nuha M.& Abd al-Azim, Hamdi. A descriptive study of plasma cell dyscrasias in Egyptian population. Journal of the Egyptian National Cancer Institute. 2014. Vol. 26, no. 2, pp.67-71.
https://search.emarefa.net/detail/BIM-380283

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 71

رقم السجل

BIM-380283