A descriptive study of plasma cell dyscrasias in Egyptian population
Joint Authors
Qasim, Hibah A.
Qasim, Nimat M.
al-Zawam, Hamdi
al-Husayni, Nuha M.
Abd al-Azim, Hamdi
al-Nahhas, Tamir
Source
Journal of the Egyptian National Cancer Institute
Issue
Vol. 26, Issue 2 (30 Jun. 2014), pp.67-71, 5 p.
Publisher
Cairo University National Cancer Institute
Publication Date
2014-06-30
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Plasma cell dyscrasias (PCDs) refer to a spectrum of disorders characterized by the monoclonal proliferation of lymphoplasmacytic cells in the bone marrow and, sometimes, tissue deposition of monoclonal immunoglobulins or their components.
These disorders include multiple myeloma (MM) and Waldenstro¨ m’s macroglobulinemia, as well as rare conditions such as light-chain deposition disease (LCDD) and heavy-chain diseases (HCDs).
The worldwide annual incidence of MM is estimated at 86,000, which is approximately 0.8 % of all new cancer cases.
Purpose : Our retrospective study aims to highlight the immunologic and epidemiological features of PCDs mainly MM in Egyptian patients and compare our results with those of other populations.
Methods : Two hundred seventeen Egyptian patients with PCD were enrolled in the study.
Serum, urine protein electrophoresis and immunofixation were used to demonstrate M protein.
Results: One hundred thirty-eight patients (63.6 %) had IgG monoclonal band, 38 patients (17.5 %) had IgA, 12 patients (5.5 %) had Waldenstro¨ m’s macroglobulinemia (IgM monoclonal band) and 29 patients (13.4 %) were light chain myeloma.
One hundred fifty-one (70 %) were Kappa chain positive and 66 patients (30 %) were lumbda positive.
Conventional cytogenetics was available for 40 patients ; of them12 patients (30 %) showed 13q-.
Mean OS was 37.5 months (1–84 months).
Survival analysis was statistically insignificant according to age, sex and ISS or type of treatment (P value > 0.05).
American Psychological Association (APA)
Qasim, Nimat M.& al-Zawam, Hamdi& Qasim, Hibah A.& al-Nahhas, Tamir& al-Husayni, Nuha M.& Abd al-Azim, Hamdi. 2014. A descriptive study of plasma cell dyscrasias in Egyptian population. Journal of the Egyptian National Cancer Institute،Vol. 26, no. 2, pp.67-71.
https://search.emarefa.net/detail/BIM-380283
Modern Language Association (MLA)
Qasim, Nimat M.…[et al.]. A descriptive study of plasma cell dyscrasias in Egyptian population. Journal of the Egyptian National Cancer Institute Vol. 26, no. 2 (2014), pp.67-71.
https://search.emarefa.net/detail/BIM-380283
American Medical Association (AMA)
Qasim, Nimat M.& al-Zawam, Hamdi& Qasim, Hibah A.& al-Nahhas, Tamir& al-Husayni, Nuha M.& Abd al-Azim, Hamdi. A descriptive study of plasma cell dyscrasias in Egyptian population. Journal of the Egyptian National Cancer Institute. 2014. Vol. 26, no. 2, pp.67-71.
https://search.emarefa.net/detail/BIM-380283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 71
Record ID
BIM-380283