Cytokines profile in newly diagnosed children with type 1 diabetes mellitus
المؤلف
المصدر
Journal of the Faculty of Medicine Baghdad
العدد
المجلد 51، العدد 3 (30 سبتمبر/أيلول 2009)، ص ص. 295-299، 5ص.
الناشر
تاريخ النشر
2009-09-30
دولة النشر
العراق
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Cytokines have long been implicated in the pathogenesis of autoimmune diabetes in a number of studies, and playing a role in the initiation of β-cell damaging process.
The objective of this study is to gain more understanding about the role of cytokines in initiation of T1DM, through assessment of IFN-γ, IL-10 and IL-6 in diabetic patients.
Patients and methods: A total of 60 patients who were newly diagnosed as having T1DM (diagnosed less than five months) were included in the present study.
Fifty apparently healthy control subjects were underwent the measurement of serum IFN-γ, IL-10 and IL-6 by ELISA.
Results : Higher serum levels of IFN-γ, IL-10, and Il-6 were observed in the investigated patients ≤10 years (75.60, 104.92, 147.6 pg / ml respectively) compared to controls (42.66, 57.01, 80.4 pg/ml respectively).
The statistical analysis revealed a significant difference between patients and controls (P1 = 0.005, 0.003, 0.036 respectively).
The mean levels of serum IFN-γ, IL-10, and Il-6 were also significantly elevated in >10 years old patients (70.78, 84.22, 171.8 pg/ml respectively) than controls (40.39, 59.50, 81.6 pg / ml respectively), (P1 = 0.006, 0.037, 0.04 respectively).
A statistically difference of mean IL-10 concentration appears between patients in both age groups (P2 = 0.04).
No significant differences appear in the mean serum concentrations of IFN-γ, and IL-6 between the two age groups (P2 = 0.73, 0.07 respectively).
Conclusions : In children with diabetes, a significant elevation of serum levels of IFN-γ, IL-10 and IL-6 were observed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salih, Iman M.. 2009. Cytokines profile in newly diagnosed children with type 1 diabetes mellitus. Journal of the Faculty of Medicine Baghdad،Vol. 51, no. 3, pp.295-299.
https://search.emarefa.net/detail/BIM-380447
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salih, Iman M.. Cytokines profile in newly diagnosed children with type 1 diabetes mellitus. Journal of the Faculty of Medicine Baghdad Vol. 51, no. 3 (2009), pp.295-299.
https://search.emarefa.net/detail/BIM-380447
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salih, Iman M.. Cytokines profile in newly diagnosed children with type 1 diabetes mellitus. Journal of the Faculty of Medicine Baghdad. 2009. Vol. 51, no. 3, pp.295-299.
https://search.emarefa.net/detail/BIM-380447
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 298-299
رقم السجل
BIM-380447
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر