Cytokines profile in newly diagnosed children with type 1 diabetes mellitus
Author
Source
Journal of the Faculty of Medicine Baghdad
Issue
Vol. 51, Issue 3 (30 Sep. 2009), pp.295-299, 5 p.
Publisher
University of Baghdad Faculty of Medicine
Publication Date
2009-09-30
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background : Cytokines have long been implicated in the pathogenesis of autoimmune diabetes in a number of studies, and playing a role in the initiation of β-cell damaging process.
The objective of this study is to gain more understanding about the role of cytokines in initiation of T1DM, through assessment of IFN-γ, IL-10 and IL-6 in diabetic patients.
Patients and methods: A total of 60 patients who were newly diagnosed as having T1DM (diagnosed less than five months) were included in the present study.
Fifty apparently healthy control subjects were underwent the measurement of serum IFN-γ, IL-10 and IL-6 by ELISA.
Results : Higher serum levels of IFN-γ, IL-10, and Il-6 were observed in the investigated patients ≤10 years (75.60, 104.92, 147.6 pg / ml respectively) compared to controls (42.66, 57.01, 80.4 pg/ml respectively).
The statistical analysis revealed a significant difference between patients and controls (P1 = 0.005, 0.003, 0.036 respectively).
The mean levels of serum IFN-γ, IL-10, and Il-6 were also significantly elevated in >10 years old patients (70.78, 84.22, 171.8 pg/ml respectively) than controls (40.39, 59.50, 81.6 pg / ml respectively), (P1 = 0.006, 0.037, 0.04 respectively).
A statistically difference of mean IL-10 concentration appears between patients in both age groups (P2 = 0.04).
No significant differences appear in the mean serum concentrations of IFN-γ, and IL-6 between the two age groups (P2 = 0.73, 0.07 respectively).
Conclusions : In children with diabetes, a significant elevation of serum levels of IFN-γ, IL-10 and IL-6 were observed.
American Psychological Association (APA)
Salih, Iman M.. 2009. Cytokines profile in newly diagnosed children with type 1 diabetes mellitus. Journal of the Faculty of Medicine Baghdad،Vol. 51, no. 3, pp.295-299.
https://search.emarefa.net/detail/BIM-380447
Modern Language Association (MLA)
Salih, Iman M.. Cytokines profile in newly diagnosed children with type 1 diabetes mellitus. Journal of the Faculty of Medicine Baghdad Vol. 51, no. 3 (2009), pp.295-299.
https://search.emarefa.net/detail/BIM-380447
American Medical Association (AMA)
Salih, Iman M.. Cytokines profile in newly diagnosed children with type 1 diabetes mellitus. Journal of the Faculty of Medicine Baghdad. 2009. Vol. 51, no. 3, pp.295-299.
https://search.emarefa.net/detail/BIM-380447
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 298-299
Record ID
BIM-380447