Vitamin C antioxidant effects in brain of albino mice after seizures and status epilepticus induced by pentylenetetrazole (PTZ)
المؤلفون المشاركون
Khalil, Shirin M.
Uways, Muhammad M.
Ali, Dina A.
Kamil, Shiri N.
المصدر
Suez Canal University Medical Journal
العدد
المجلد 16، العدد 1 (30 يونيو/حزيران 2013)، ص ص. 11-17، 7ص.
الناشر
تاريخ النشر
2013-06-30
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Aim : Oxidative stress has been implicated in the neurological diseases, one of them is epilepsy.
Therefore, this study was conducted to determine the effect of vitamin C as an acute antioxidant protective treatment of epilepsy in mice.
Materials and Methods : Seventy-eight male albino mice were divided into six groups.
The first group was a normal control group that received NaCl, 0.9 % (i.
p.).
The second group received PTZ (65 mg / kg, i.
p.) as a single convulsive dose.
The third and fourth groups received vitamin C (500 mg / kg / day, i.
p.) and vitamin C (1000mg / kg, i.
p.) respective-ly.
The fifth and sixth groups received vitamin C (500 mg / kg / day, i.
p.) and vitamin C (1000 mg / kg, i.
p.) respectively, then after 30 minutes both received Pentylenetetrazole (PTZ) (65 mg / kg i.
p.) as a single convulsive dose.
Behavioral assessment was done immediately after injections using Ra-cine scale and rotarod tests then after 24 hours, the animals were killed and brain tissue homoge-nates were prepared to measure lipid peroxide (Malondialdehyde) and catalase activity.
Results : Vitamin C showed decreased percentage of seizures, prolonged latency to 1st seizure, improved motor coordination, decreased lipid peroxide level and increased catalase activity.
No difference in results between groups received vitamin C (500 mg / kg, i.
p.) or (1000 mg / kg, i.
p.).
Conclusion : Vitamin C was proven to be a potential candidate for decreasing risk of epilepsy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Dina A.& Uways, Muhammad M.& Khalil, Shirin M.& Kamil, Shiri N.. 2013. Vitamin C antioxidant effects in brain of albino mice after seizures and status epilepticus induced by pentylenetetrazole (PTZ). Suez Canal University Medical Journal،Vol. 16, no. 1, pp.11-17.
https://search.emarefa.net/detail/BIM-380998
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uways, Muhammad M.…[et al.]. Vitamin C antioxidant effects in brain of albino mice after seizures and status epilepticus induced by pentylenetetrazole (PTZ). Suez Canal University Medical Journal Vol. 16, no. 1 (2013), pp.11-17.
https://search.emarefa.net/detail/BIM-380998
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Dina A.& Uways, Muhammad M.& Khalil, Shirin M.& Kamil, Shiri N.. Vitamin C antioxidant effects in brain of albino mice after seizures and status epilepticus induced by pentylenetetrazole (PTZ). Suez Canal University Medical Journal. 2013. Vol. 16, no. 1, pp.11-17.
https://search.emarefa.net/detail/BIM-380998
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 16-17
رقم السجل
BIM-380998
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر