Chemokine receptor CXCR3 in peripheral blood in rheumatoid arthritis patients : its relation to disease activity and joint destruction
المؤلفون المشاركون
al-Barbari, Amal M.
Isa, Salwa A.
Zaytun, Husam
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 40، العدد 2 (30 يونيو/حزيران 2013)، ص ص. 75-80، 6ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2013-06-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Aim of the work The aim of this study was to investigate the role of CXCR3 in rheumatoid arthritis (RA) and its relation to disease activity, synovitis, and joint destruction.
Patients and methods This study included 30 RA patients and 20 healthy controls.
Morning stiffness, disease activity for 28 joint indices score (DAS-28), and Modified Health Assessment Questionnaire scores were estimated.
Levels of erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, hemoglobin, and CXCR3 in peripheral blood were also determined.
Radiological assessment included determination of the Van der Heijde modification scores for hands and feet and MRI scores for wrists and metacarpophalangeal joints for detection of synovitis and bone defects.
Results CXCR3 levels in peripheral blood were found to be increased in RA patients compared with controls (Po0.001) and in patients with moderate and high RA activity scores.
CXCR3 levels in peripheral blood were positively correlated with DAS-28 levels, Van der Heijde modification scores, and MRI scores for wrists and metacarpophalangeal joints for detection of synovitis and bone erosion.
Conclusion This study demonstrates an important role of CXCR3 in the pathogenesis of chronic inflammation in RA and that CXCR3 blockade may offer a new strategy for reducing the severity and inflammatory reaction in RA patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Barbari, Amal M.& Isa, Salwa A.& Zaytun, Husam. 2013. Chemokine receptor CXCR3 in peripheral blood in rheumatoid arthritis patients : its relation to disease activity and joint destruction. Egyptian Rheumatology and Rehabilitation،Vol. 40, no. 2, pp.75-80.
https://search.emarefa.net/detail/BIM-381114
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Barbari, Amal M.…[et al.]. Chemokine receptor CXCR3 in peripheral blood in rheumatoid arthritis patients : its relation to disease activity and joint destruction. Egyptian Rheumatology and Rehabilitation Vol. 40, no. 2 (Apr. / Jun. 2013), pp.75-80.
https://search.emarefa.net/detail/BIM-381114
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Barbari, Amal M.& Isa, Salwa A.& Zaytun, Husam. Chemokine receptor CXCR3 in peripheral blood in rheumatoid arthritis patients : its relation to disease activity and joint destruction. Egyptian Rheumatology and Rehabilitation. 2013. Vol. 40, no. 2, pp.75-80.
https://search.emarefa.net/detail/BIM-381114
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 79-80
رقم السجل
BIM-381114
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر