Chemokine receptor CXCR3 in peripheral blood in rheumatoid arthritis patients : its relation to disease activity and joint destruction
Joint Authors
al-Barbari, Amal M.
Isa, Salwa A.
Zaytun, Husam
Source
Egyptian Rheumatology and Rehabilitation
Issue
Vol. 40, Issue 2 (30 Jun. 2013), pp.75-80, 6 p.
Publisher
The Egyptian Society for Rheumatology and Rehabilitation
Publication Date
2013-06-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Topics
Abstract EN
Aim of the work The aim of this study was to investigate the role of CXCR3 in rheumatoid arthritis (RA) and its relation to disease activity, synovitis, and joint destruction.
Patients and methods This study included 30 RA patients and 20 healthy controls.
Morning stiffness, disease activity for 28 joint indices score (DAS-28), and Modified Health Assessment Questionnaire scores were estimated.
Levels of erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, hemoglobin, and CXCR3 in peripheral blood were also determined.
Radiological assessment included determination of the Van der Heijde modification scores for hands and feet and MRI scores for wrists and metacarpophalangeal joints for detection of synovitis and bone defects.
Results CXCR3 levels in peripheral blood were found to be increased in RA patients compared with controls (Po0.001) and in patients with moderate and high RA activity scores.
CXCR3 levels in peripheral blood were positively correlated with DAS-28 levels, Van der Heijde modification scores, and MRI scores for wrists and metacarpophalangeal joints for detection of synovitis and bone erosion.
Conclusion This study demonstrates an important role of CXCR3 in the pathogenesis of chronic inflammation in RA and that CXCR3 blockade may offer a new strategy for reducing the severity and inflammatory reaction in RA patients.
American Psychological Association (APA)
al-Barbari, Amal M.& Isa, Salwa A.& Zaytun, Husam. 2013. Chemokine receptor CXCR3 in peripheral blood in rheumatoid arthritis patients : its relation to disease activity and joint destruction. Egyptian Rheumatology and Rehabilitation،Vol. 40, no. 2, pp.75-80.
https://search.emarefa.net/detail/BIM-381114
Modern Language Association (MLA)
al-Barbari, Amal M.…[et al.]. Chemokine receptor CXCR3 in peripheral blood in rheumatoid arthritis patients : its relation to disease activity and joint destruction. Egyptian Rheumatology and Rehabilitation Vol. 40, no. 2 (Apr. / Jun. 2013), pp.75-80.
https://search.emarefa.net/detail/BIM-381114
American Medical Association (AMA)
al-Barbari, Amal M.& Isa, Salwa A.& Zaytun, Husam. Chemokine receptor CXCR3 in peripheral blood in rheumatoid arthritis patients : its relation to disease activity and joint destruction. Egyptian Rheumatology and Rehabilitation. 2013. Vol. 40, no. 2, pp.75-80.
https://search.emarefa.net/detail/BIM-381114
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 79-80
Record ID
BIM-381114