Synthesis of ibuprofen-PEG prodrug and study the hydrolysis at different phosphate buffers

الملخص EN

The present study is conducted to prepare Ibuprofen as polymeric prodrug to improve its important physiochemical properties, increasing water solubility and decrease its side-effects.

The product is characterize by using chemical and spectral methods .Then controlled release of Ibuprofen in from its polymer, in different phosphate buffers ( pH =8.5, 7.5 and 1).The result show the percentage release of Ibuprofen was high at basic pH.