Synthesis of ibuprofen-PEG prodrug and study the hydrolysis at different phosphate buffers
Other Title(s)
تحضير نظام تحميل بولي اثيلين كلايكول-ابوبروفين و دراسة التحلل في محاليل فوسفات منظمة مختلفة
Author
al-Rabii, Liqa Abd al-Rida Rahim
Source
Journal of Basrah Researches : Sciences
Issue
Vol. 36, Issue 3A (30 Jun. 2010)8 p.
Publisher
University of Basrah College of Education for Pure Sciences
Publication Date
2010-06-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Pharmacy, Health & Medical Sciences
Topics
Abstract AR
يتضمن البحث تحضير دواء ابوبروفين (البروفين) بصيغة البوليمرية و شخصت النواتج باستخدام الطرق الكيميائية و الطيفية، و ذلك لتقليل التأثيرات الجانبية المصاحبة عند استخدامه كالقرحة و للتحسين من ذائبيته في الماء بالتالي ممكن السيطرة أو التحكم في تحرره في محاليل الفوسفات المنظمة و لقيم حامضية مختلفة.
كما درست ظروف تحرر الدواء عند قيم مختلفة من الدالة الحامضية (7.5, 1 و 8.5) و استنتج بأن نسبة تحرر الدواء عند الدالة القاعدية أكثر من غيرها.
Abstract EN
The present study is conducted to prepare Ibuprofen as polymeric prodrug to improve its important physiochemical properties, increasing water solubility and decrease its side-effects.
The product is characterize by using chemical and spectral methods .Then controlled release of Ibuprofen in from its polymer, in different phosphate buffers ( pH =8.5, 7.5 and 1).The result show the percentage release of Ibuprofen was high at basic pH.
American Psychological Association (APA)
al-Rabii, Liqa Abd al-Rida Rahim. 2010. Synthesis of ibuprofen-PEG prodrug and study the hydrolysis at different phosphate buffers. Journal of Basrah Researches : Sciences،Vol. 36, no. 3A.
https://search.emarefa.net/detail/BIM-381799
Modern Language Association (MLA)
al-Rabii, Liqa Abd al-Rida Rahim. Synthesis of ibuprofen-PEG prodrug and study the hydrolysis at different phosphate buffers. Journal of Basrah Researches : Sciences Vol. 36, no. 3A (Jun. 2010).
https://search.emarefa.net/detail/BIM-381799
American Medical Association (AMA)
al-Rabii, Liqa Abd al-Rida Rahim. Synthesis of ibuprofen-PEG prodrug and study the hydrolysis at different phosphate buffers. Journal of Basrah Researches : Sciences. 2010. Vol. 36, no. 3A.
https://search.emarefa.net/detail/BIM-381799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-381799
