Synthesis and characterization of novel compounds containing of imidazolidinone and oxazepine rings

الملخص EN

The compound 3-[4̄-(4˭-methoxy benzoyloxy) benzylideneamino]-2-thioxo-imidazolidine-4-one [III] was prepared from the cyclization of thiosemicarbazone [II] with ethyl α -chloroacetate in the presence of fused sodium acetate.

Treatment the later compound with acetic anhydride yielded the corresponding 1-Acetyl-3-[4̄- (4˭- methoxy benzoyloxy) benzylideneamino] –2– thioxo -imidazolidine-4-one [IV].

1,3-Oxazepine derivatives [V]a-d and [VI]a-d are obtained from the reaction of compounds[III] and [IV] with different acid anhydrides, in dry benzene.

The FTIR and 1HNMR spectroscopy are indicated a good evidence for the formation of the synthesized compounds.

Some of the synthesized compounds have been screened against E.coli, Staph.

aureus, Psenudomonsaeruginosa and Bascillus cereus .

They exhibited moderate to weak antibacterial activity unless compound [V]d did not show any biological activity.