Synthesis and characterization of novel compounds containing of imidazolidinone and oxazepine rings
Other Title(s)
تحضير و تشخيص مركبات جديدة تحتوي على حلقتي الايميدازولدينون و الاكسازبيين
Joint Authors
Mukhlis, Abd al-Jabbar Abd al-Qadir
Muhsin, Talib Rashid
al-Jazrawi, Jumbad Hurmuz Tuma Musa
Source
Ibn al-Haitham Journal for Pure and Applied Science
Issue
Vol. 25, Issue 3 (31 Dec. 2012), pp.276-283, 8 p.
Publisher
University of Baghdad College of Education for Pure Science / Ibn al-Haitham
Publication Date
2012-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Topics
Abstract AR
حضر الايميدازولدين -4- ون [III] من الغلق الحلقي للثايوسيميكاربازون [II] مع اثيل كلورو اسيتات بوجود خلات الصوديوم المنصهرة تمت معاملة المركب الأخير مع انهيدريد الخليك لينتج المركب المقابل [VI].
حضرت مشتقات الاوكسازبين [V] و [VI] من تفاعل المركب [III] و [IV] مع انهيدريدات متنوعة على التوالي في البنزين الجاف.
أثبتت صحة التراكيب للمركبات المحضرة باستعمال طيف FTIR و طيف الرنين النووي المغناطيسي 1NMR H.
درست الفعالية البايولوجية لبعض من المركبات المحضرة ضد أنواع من البكتيريا E.coli , Staph.
Aureu, Psenudomonsaeruginosa Bascillus cereus و بينت النتائج أن أغلب المركبات أظهرت فعالية بايولوجية ضد البكتيريا المستخدمة تراوحت بين المتوسطة إلى الضعيفة و لم يظهر المركب [V]d أي فعالية ضد هذه الأنواع من البكتيريا.
Abstract EN
The compound 3-[4̄-(4˭-methoxy benzoyloxy) benzylideneamino]-2-thioxo-imidazolidine-4-one [III] was prepared from the cyclization of thiosemicarbazone [II] with ethyl α -chloroacetate in the presence of fused sodium acetate.
Treatment the later compound with acetic anhydride yielded the corresponding 1-Acetyl-3-[4̄- (4˭- methoxy benzoyloxy) benzylideneamino] –2– thioxo -imidazolidine-4-one [IV].
1,3-Oxazepine derivatives [V]a-d and [VI]a-d are obtained from the reaction of compounds[III] and [IV] with different acid anhydrides, in dry benzene.
The FTIR and 1HNMR spectroscopy are indicated a good evidence for the formation of the synthesized compounds.
Some of the synthesized compounds have been screened against E.coli, Staph.
aureus, Psenudomonsaeruginosa and Bascillus cereus .
They exhibited moderate to weak antibacterial activity unless compound [V]d did not show any biological activity.
American Psychological Association (APA)
Muhsin, Talib Rashid& al-Jazrawi, Jumbad Hurmuz Tuma Musa& Mukhlis, Abd al-Jabbar Abd al-Qadir. 2012. Synthesis and characterization of novel compounds containing of imidazolidinone and oxazepine rings. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 25, no. 3, pp.276-283.
https://search.emarefa.net/detail/BIM-382962
Modern Language Association (MLA)
Muhsin, Talib Rashid…[et al.]. Synthesis and characterization of novel compounds containing of imidazolidinone and oxazepine rings. Ibn al-Haitham Journal for Pure and Applied Science Vol. 25, no. 3 (2012), pp.276-283.
https://search.emarefa.net/detail/BIM-382962
American Medical Association (AMA)
Muhsin, Talib Rashid& al-Jazrawi, Jumbad Hurmuz Tuma Musa& Mukhlis, Abd al-Jabbar Abd al-Qadir. Synthesis and characterization of novel compounds containing of imidazolidinone and oxazepine rings. Ibn al-Haitham Journal for Pure and Applied Science. 2012. Vol. 25, no. 3, pp.276-283.
https://search.emarefa.net/detail/BIM-382962
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 281-282
Record ID
BIM-382962
