Fibronectin regulation by vitamin c treatment in kidneys of nicotinic mice offspring
المؤلفون المشاركون
Nikravesh, Muhammad Rida
Pahang, Hasan
Jalali, Mahdi
Bideskan, Alirida Ibrahimzadah
Zargari, Peyman
Nabavi, Ariane Sadr
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 16، العدد 7 (31 يوليو/تموز 2014)، ص ص. 1-6، 6ص.
الناشر
تاريخ النشر
2014-07-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Maternal cigarette smoking causes health risks and developmental defects in the offspring.
So far, many studies have been conducted to suppress the effects of nicotine.
However, the effects of coadministration of vitamin C and nicotine on extracellular matrix have not gained enough attention.
Objectives : This study decided to investigate the effects of vitamin C on fibronectin expression in kidneys of mice offspring, treated with nicotine.
Materials and Methods : Eighteen female pregnant BALB / c mice were selected; six mice in the experimental group 1 (exp 1) received nicotine (3 mg / kg / day), six mice in the experimental group 2 (exp 2) received 3 mg / kg / day nicotine and 9 mg / kg / day vitamin C simultaneously, and six were used as the control group and received 3 mL / kg / day normal saline via intraperitoneal (IP) injection parallel to other groups, since the 6th day of gestation to the end of prenatal period.
In the first days of delivery, fibronectin content of neonatal kidneys was studied by immunohistochemistry (IHC) assay and gene expression was studied by the real-time PCR.
Results : IHC results showed that fibronectin reaction significantly increased in proximal convoluted tubules of exp 1 compared with the control offspring; on the other hand, fibronectin reaction decreased in the mice offspring of exp 2.
Gene expression results showed that fibronectin expression in the exp 1 offspring significantly increased compared with the control ones and fibronectin expression decreased in the mice offspring of exp 2.
Conclusions : This study revealed that vitamin C could reduce the fibronectin accumulation effects of nicotine on kidney.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pahang, Hasan& Nikravesh, Muhammad Rida& Jalali, Mahdi& Bideskan, Alirida Ibrahimzadah& Zargari, Peyman& Nabavi, Ariane Sadr. 2014. Fibronectin regulation by vitamin c treatment in kidneys of nicotinic mice offspring. Iranian Red Crescent Medical Journal،Vol. 16, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-387607
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nikravesh, Muhammad Rida…[et al.]. Fibronectin regulation by vitamin c treatment in kidneys of nicotinic mice offspring. Iranian Red Crescent Medical Journal Vol. 16, no. 7 (Jul. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-387607
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pahang, Hasan& Nikravesh, Muhammad Rida& Jalali, Mahdi& Bideskan, Alirida Ibrahimzadah& Zargari, Peyman& Nabavi, Ariane Sadr. Fibronectin regulation by vitamin c treatment in kidneys of nicotinic mice offspring. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-387607
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 5-6
رقم السجل
BIM-387607
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر