Fibronectin regulation by vitamin c treatment in kidneys of nicotinic mice offspring
Joint Authors
Nikravesh, Muhammad Rida
Pahang, Hasan
Jalali, Mahdi
Bideskan, Alirida Ibrahimzadah
Zargari, Peyman
Nabavi, Ariane Sadr
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 16, Issue 7 (31 Jul. 2014), pp.1-6, 6 p.
Publisher
Publication Date
2014-07-31
Country of Publication
United Arab Emirates
No. of Pages
6
Main Subjects
Topics
Abstract EN
Background : Maternal cigarette smoking causes health risks and developmental defects in the offspring.
So far, many studies have been conducted to suppress the effects of nicotine.
However, the effects of coadministration of vitamin C and nicotine on extracellular matrix have not gained enough attention.
Objectives : This study decided to investigate the effects of vitamin C on fibronectin expression in kidneys of mice offspring, treated with nicotine.
Materials and Methods : Eighteen female pregnant BALB / c mice were selected; six mice in the experimental group 1 (exp 1) received nicotine (3 mg / kg / day), six mice in the experimental group 2 (exp 2) received 3 mg / kg / day nicotine and 9 mg / kg / day vitamin C simultaneously, and six were used as the control group and received 3 mL / kg / day normal saline via intraperitoneal (IP) injection parallel to other groups, since the 6th day of gestation to the end of prenatal period.
In the first days of delivery, fibronectin content of neonatal kidneys was studied by immunohistochemistry (IHC) assay and gene expression was studied by the real-time PCR.
Results : IHC results showed that fibronectin reaction significantly increased in proximal convoluted tubules of exp 1 compared with the control offspring; on the other hand, fibronectin reaction decreased in the mice offspring of exp 2.
Gene expression results showed that fibronectin expression in the exp 1 offspring significantly increased compared with the control ones and fibronectin expression decreased in the mice offspring of exp 2.
Conclusions : This study revealed that vitamin C could reduce the fibronectin accumulation effects of nicotine on kidney.
American Psychological Association (APA)
Pahang, Hasan& Nikravesh, Muhammad Rida& Jalali, Mahdi& Bideskan, Alirida Ibrahimzadah& Zargari, Peyman& Nabavi, Ariane Sadr. 2014. Fibronectin regulation by vitamin c treatment in kidneys of nicotinic mice offspring. Iranian Red Crescent Medical Journal،Vol. 16, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-387607
Modern Language Association (MLA)
Pahang, Hasan…[et al.]. Fibronectin regulation by vitamin c treatment in kidneys of nicotinic mice offspring. Iranian Red Crescent Medical Journal Vol. 16, no. 7 (Jul. 2014), pp.1-6.
https://search.emarefa.net/detail/BIM-387607
American Medical Association (AMA)
Pahang, Hasan& Nikravesh, Muhammad Rida& Jalali, Mahdi& Bideskan, Alirida Ibrahimzadah& Zargari, Peyman& Nabavi, Ariane Sadr. Fibronectin regulation by vitamin c treatment in kidneys of nicotinic mice offspring. Iranian Red Crescent Medical Journal. 2014. Vol. 16, no. 7, pp.1-6.
https://search.emarefa.net/detail/BIM-387607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 5-6
Record ID
BIM-387607