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Immunophenotypic diagnosis of acute lymphoblastic leukemia using flow cytometry : experience at king Hussein Medical Center
المؤلفون المشاركون
Kamal, Nazmi
Haddad, Farid
Khasawinah, Rami
Warikat, Abd al-Razzaq
المصدر
Journal of the Royal Medical Services
العدد
المجلد 21، العدد 2 (30 يونيو/حزيران 2014)، ص ص. 21-26، 6ص.
الناشر
الخدمات الطبية الملكية الأردنية
تاريخ النشر
2014-06-30
دولة النشر
الأردن
عدد الصفحات
6
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective : To identify the importance of flow cytometry (FCM) in diagnosis and subclassifying acute lymphoblastic leukemia, and to highlight its capability to detect antigen aberration.
Method : The Results of flow cytometry for 165 patients, between January 2006 and December 2011 who were diagnosed with acute lymphoblastic leukemia (ALL) were retrospectively reviewed with respect to age and gender distribution and immunophenotypic findings.
Results : 63 % of patients were children (104 out of 165 patients) with age less than fourteen years old.
114 patients were male while 51 patients were female with male to female ratio 2.2: 1.
Precursor-B- acute lymphoblastic leukemia represents eighty percent (132 patients) of cases, of 106 patients (87.6 %) were [CD10 / CD19] positive,125 patients (94.7 %) were positive for cytoplasmic CD79a, 126/129 (97.6 %) were positive for HLA-DR, and 15 patients (11.36 %) were CD10 negative.
Aberrant myeloid antigen expression was noted ; CD33 and CD13 were positive in 15/113 (13.3 %) and 2/108 (1.85 %) respectively.
On the other hand precursor-T- acute lymphoblastic leukemias were found in thirty three patients, 84.4% of them were Anti-TdT positive, and all were negative for B-cell markers.
Myeloid antigen expression results were as follows ; 1/29 (3.4 %) and 2/29 (6.9 %) positive for CD33 and CD13 respectively Conclusion : Flow cytometry is a golden tool in diagnosis and identifying ALL subtypes.
Precursor-B- acute lymphoblastic leukemia represents most of ALL cases with minority of cases are CD10negative.
Aberrant myeloid antigen expression would not change the diagnosis of ALL in either B- or T- subtypes.
Further clinical correlation is needed to figure out aberrant markers prognostic implications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Haddad, Farid& Warikat, Abd al-Razzaq& Khasawinah, Rami& Kamal, Nazmi. 2014. Immunophenotypic diagnosis of acute lymphoblastic leukemia using flow cytometry : experience at king Hussein Medical Center. Journal of the Royal Medical Services،Vol. 21, no. 2, pp.21-26.
https://search.emarefa.net/detail/BIM-390266
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Haddad, Farid…[et al.]. Immunophenotypic diagnosis of acute lymphoblastic leukemia using flow cytometry : experience at king Hussein Medical Center. Journal of the Royal Medical Services Vol. 21, no. 2 (Jun. 2014), pp.21-26.
https://search.emarefa.net/detail/BIM-390266
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Haddad, Farid& Warikat, Abd al-Razzaq& Khasawinah, Rami& Kamal, Nazmi. Immunophenotypic diagnosis of acute lymphoblastic leukemia using flow cytometry : experience at king Hussein Medical Center. Journal of the Royal Medical Services. 2014. Vol. 21, no. 2, pp.21-26.
https://search.emarefa.net/detail/BIM-390266
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 25-26
رقم السجل
BIM-390266
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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