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Durability of sustained virological response and long term follow up to pegylated interferon and ribavirin in treated patients with chronic hepatitis C
المؤلفون المشاركون
al-Samadi, Sami
Hammudi, Wasim
Lutfi, Karim
Uzayzi, Muadh
Niomat, Yusuf
المصدر
Journal of the Royal Medical Services
العدد
المجلد 21، العدد 2 (30 يونيو/حزيران 2014)، ص ص. 6-12، 7ص.
الناشر
الخدمات الطبية الملكية الأردنية
تاريخ النشر
2014-06-30
دولة النشر
الأردن
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective : To study the clinical, biochemical and virological long-term outcome in chronic hepatitis C patients with a Sustained Virological Response after Pegylated Interferon plus ribavirin combination therapy.
Methods : Twenty eight patients with a Sustained Virological Response after treatment with Pegylated Interferon plus ribavirin were included in a 5-year follow-up study in a single Gastroenterology & Hepatology center, based on standard clinical practice.
Clinical and ultrasonic evaluation, liver function tests, alpha-fetoprotein and hepatitis C virus RNA by PCR were performed annually for a period of 5 years.
Results : The mean follow-up period of the 28 patients was 67 ± 4 months after they obtained a sustained virological response.
Eleven patients (39.2 %) presented with high fibrosis score (Metavir >3) before treatment.
Seventeen patients (60.7 %) had genotype 4, nine patients (32.1 %) genotype 1, one patient genotype 2 and one patient genotype 3.
One patient (3.5 %) showed evidence of hepatic decompensation.
One patient (3.5 %) showed virological relapse after achieving sustained virological response.
At the end of the 5-year follow-up there were no deaths, no elevation in liver function tests and no hepatocellular carcinoma.
Conclusion : The long-term outcome of patients with sustained virological response to Pegylated Interferon plus ribavirin was maintained in 96.5% with one patient having virological relapse, indicating that Long term recurrence rate to combination therapy was very low.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hammudi, Wasim& al-Samadi, Sami& Lutfi, Karim& Uzayzi, Muadh& Niomat, Yusuf. 2014. Durability of sustained virological response and long term follow up to pegylated interferon and ribavirin in treated patients with chronic hepatitis C. Journal of the Royal Medical Services،Vol. 21, no. 2, pp.6-12.
https://search.emarefa.net/detail/BIM-390374
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hammudi, Wasim…[et al.]. Durability of sustained virological response and long term follow up to pegylated interferon and ribavirin in treated patients with chronic hepatitis C. Journal of the Royal Medical Services Vol. 21, no. 2 (Jun. 2014), pp.6-12.
https://search.emarefa.net/detail/BIM-390374
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hammudi, Wasim& al-Samadi, Sami& Lutfi, Karim& Uzayzi, Muadh& Niomat, Yusuf. Durability of sustained virological response and long term follow up to pegylated interferon and ribavirin in treated patients with chronic hepatitis C. Journal of the Royal Medical Services. 2014. Vol. 21, no. 2, pp.6-12.
https://search.emarefa.net/detail/BIM-390374
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes appendix : p. 12
رقم السجل
BIM-390374
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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