Durability of sustained virological response and long term follow up to pegylated interferon and ribavirin in treated patients with chronic hepatitis C
Joint Authors
al-Samadi, Sami
Hammudi, Wasim
Lutfi, Karim
Uzayzi, Muadh
Niomat, Yusuf
Source
Journal of the Royal Medical Services
Issue
Vol. 21, Issue 2 (30 Jun. 2014), pp.6-12, 7 p.
Publisher
The Royal Medical Services Jordan Armed Forces
Publication Date
2014-06-30
Country of Publication
Jordan
No. of Pages
7
Main Subjects
Topics
Abstract EN
Objective : To study the clinical, biochemical and virological long-term outcome in chronic hepatitis C patients with a Sustained Virological Response after Pegylated Interferon plus ribavirin combination therapy.
Methods : Twenty eight patients with a Sustained Virological Response after treatment with Pegylated Interferon plus ribavirin were included in a 5-year follow-up study in a single Gastroenterology & Hepatology center, based on standard clinical practice.
Clinical and ultrasonic evaluation, liver function tests, alpha-fetoprotein and hepatitis C virus RNA by PCR were performed annually for a period of 5 years.
Results : The mean follow-up period of the 28 patients was 67 ± 4 months after they obtained a sustained virological response.
Eleven patients (39.2 %) presented with high fibrosis score (Metavir >3) before treatment.
Seventeen patients (60.7 %) had genotype 4, nine patients (32.1 %) genotype 1, one patient genotype 2 and one patient genotype 3.
One patient (3.5 %) showed evidence of hepatic decompensation.
One patient (3.5 %) showed virological relapse after achieving sustained virological response.
At the end of the 5-year follow-up there were no deaths, no elevation in liver function tests and no hepatocellular carcinoma.
Conclusion : The long-term outcome of patients with sustained virological response to Pegylated Interferon plus ribavirin was maintained in 96.5% with one patient having virological relapse, indicating that Long term recurrence rate to combination therapy was very low.
American Psychological Association (APA)
Hammudi, Wasim& al-Samadi, Sami& Lutfi, Karim& Uzayzi, Muadh& Niomat, Yusuf. 2014. Durability of sustained virological response and long term follow up to pegylated interferon and ribavirin in treated patients with chronic hepatitis C. Journal of the Royal Medical Services،Vol. 21, no. 2, pp.6-12.
https://search.emarefa.net/detail/BIM-390374
Modern Language Association (MLA)
al-Samadi, Sami…[et al.]. Durability of sustained virological response and long term follow up to pegylated interferon and ribavirin in treated patients with chronic hepatitis C. Journal of the Royal Medical Services Vol. 21, no. 2 (Jun. 2014), pp.6-12.
https://search.emarefa.net/detail/BIM-390374
American Medical Association (AMA)
Hammudi, Wasim& al-Samadi, Sami& Lutfi, Karim& Uzayzi, Muadh& Niomat, Yusuf. Durability of sustained virological response and long term follow up to pegylated interferon and ribavirin in treated patients with chronic hepatitis C. Journal of the Royal Medical Services. 2014. Vol. 21, no. 2, pp.6-12.
https://search.emarefa.net/detail/BIM-390374
Data Type
Journal Articles
Language
English
Notes
Includes appendix : p. 12
Record ID
BIM-390374