Mutagenic activity of some platinum and ruthenium complexes with N-heterocyclic ligands in salmonella typhimurium TA 1530 and TA 98

الملخص EN

The mutagenic activity of some platinum and ruthenium complexes with 2,2’-biquinoline (biq) and 2-(2,-pyridyl)qumolme (pq) was examined in strains of Salmonella typhimurium TA 1530 and TA 98.

The complexes cw-[Pt(NN)X2)] (NN=biq, X=C1; NN=pq, X=C1, Br), Pt3(biq)2I6 and mer-[Ru(biq)?Cl3]*2H20 exhibit significant mutagenic activity while m^r-[Ru(pq)Cl3(C2H5OH)], [Ru(pq)Cl4].

3H20 and [Ru(pq) (DMSO)2Cl2] .0.5H20 show much weaker mutagenic activity.

The platinum complexes appear to be more active via induction of frameshift than base substitution mutations while mer-[Ru(biq)2Cl3].2H00 is highly mutagenic via base substitution.