Detection of acute renal allograft rejection by analysis of renal tissue proteomics rat models of renal transplantation
المؤلفون المشاركون
Dai, Yong
Huang, Yuanshuai
Lv, Tianyu
Wang, Kang
Li, Deping
Liu, Jianjun
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 19، العدد 6 (31 ديسمبر/كانون الأول 2008)، ص ص. 952-959، 8ص.
الناشر
تاريخ النشر
2008-12-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
At present, the diagnosis of renal allograft rejection requires a renal biopsy.
Clinical management of renal transplant patients would be improved if rapid, noninvasive and reliable biomarkers of rejection were available.
This study is designed to determine whether such protein biomarkers can be found in renal-graft tissue proteomic approach.
Orthotopic kidney transplantations were performed using Fisher (F344) or Lewis rats as donors and Lewis rats as recipients.
Hence, there were two groups of renal transplant models: one is allograft (from F344 to Lewis rats); another is syngrafts (from Lewis to Lewis rats) serving as control.
Renal tissues were collected 3, 7 and 14 days after transplantation.
As many as 18 samples were analyzed by 2D Electrophoresis and mass spectrometry (MALDI-TOF-TOF-MS).
Eleven differentially expressed proteins were identified between groups.
In conclusion, proteomic technology can detect renal tissue proteins associated with acute renal allograft rejection.
Identification of these proteins as diagnostic markers for rejection in patients' urine or sera may be useful and noninvasive, and these proteins might serve as novel therapeutic targets that also help to improve the understanding of mechanism of renal rejection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dai, Yong& Lv, Tianyu& Wang, Kang& Huang, Yuanshuai& Li, Deping& Liu, Jianjun. 2008. Detection of acute renal allograft rejection by analysis of renal tissue proteomics rat models of renal transplantation. Saudi Journal of Kidney Diseases and Transplantation،Vol. 19, no. 6, pp.952-959.
https://search.emarefa.net/detail/BIM-40183
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dai, Yong…[et al.]. Detection of acute renal allograft rejection by analysis of renal tissue proteomics rat models of renal transplantation. Saudi Journal of Kidney Diseases and Transplantation Vol. 19, no. 6 (Dec. 2008), pp.952-959.
https://search.emarefa.net/detail/BIM-40183
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dai, Yong& Lv, Tianyu& Wang, Kang& Huang, Yuanshuai& Li, Deping& Liu, Jianjun. Detection of acute renal allograft rejection by analysis of renal tissue proteomics rat models of renal transplantation. Saudi Journal of Kidney Diseases and Transplantation. 2008. Vol. 19, no. 6, pp.952-959.
https://search.emarefa.net/detail/BIM-40183
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 958-959
رقم السجل
BIM-40183
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر